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JAML junction adhesion molecule like [ Homo sapiens (human) ]

Gene ID: 120425, updated on 8-Jul-2021

Summary

Official Symbol
JAMLprovided by HGNC
Official Full Name
junction adhesion molecule likeprovided by HGNC
Primary source
HGNC:HGNC:19084
See related
Ensembl:ENSG00000160593 MIM:609770
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMICA; Gm638; AMICA1; CREA7-1; CREA7-4
Expression
Broad expression in appendix (RPKM 34.6), spleen (RPKM 24.5) and 14 other tissues See more
Orthologs
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Genomic context

See JAML in Genome Data Viewer
Location:
11q23.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (118193725..118225089, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118064440..118095726, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel beta subunit 4 Neighboring gene sodium voltage-gated channel beta subunit 2 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 18 Neighboring gene myelin protein zero like 3 Neighboring gene myelin protein zero like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37080, MGC118814, MGC118815

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
junctional adhesion molecule-like
Names
adhesion molecule AMICA
adhesion molecule interacting with CXADR antigen 1
adhesion molecule, interacts with CXADR antigen 1
dendritic-cell specific protein CREA7-1
dendritic-cell specific protein CREA7-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098526.2NP_001091996.1  junctional adhesion molecule-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_001091996.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK097285, AP002800, AY138965, DC296115
    Consensus CDS
    CCDS41723.1
    UniProtKB/Swiss-Prot
    Q86YT9
    UniProtKB/TrEMBL
    B3KUI3
    Related
    ENSP00000348635.5, ENST00000356289.10
    Conserved Domains (2) summary
    smart00410
    Location:27135
    IG_like; Immunoglobulin like
    pfam07686
    Location:26136
    V-set; Immunoglobulin V-set domain
  2. NM_001286570.2NP_001273499.1  junctional adhesion molecule-like isoform 3

    See identical proteins and their annotated locations for NP_001273499.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AK097285, AK298722, AP002800, BC100797
    Consensus CDS
    CCDS66240.1
    UniProtKB/Swiss-Prot
    Q86YT9
    UniProtKB/TrEMBL
    B3KUI3, Q496M4
    Related
    ENSP00000431218.1, ENST00000526620.5
    Conserved Domains (2) summary
    smart00410
    Location:158212
    IG_like; Immunoglobulin like
    pfam07686
    Location:397
    V-set; Immunoglobulin V-set domain
  3. NM_001286571.2NP_001273500.1  junctional adhesion molecule-like isoform 3

    See identical proteins and their annotated locations for NP_001273500.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AK097285, AP002800, BC100797
    Consensus CDS
    CCDS66240.1
    UniProtKB/Swiss-Prot
    Q86YT9
    UniProtKB/TrEMBL
    B3KUI3
    Related
    ENSP00000431614.1, ENST00000526595.5
    Conserved Domains (2) summary
    smart00410
    Location:158212
    IG_like; Immunoglobulin like
    pfam07686
    Location:397
    V-set; Immunoglobulin V-set domain
  4. NM_153206.3NP_694938.2  junctional adhesion molecule-like isoform 2

    See identical proteins and their annotated locations for NP_694938.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK094399, AK097285, AP002800, AW804077, DA090367
    Consensus CDS
    CCDS8391.1
    UniProtKB/Swiss-Prot
    Q86YT9
    UniProtKB/TrEMBL
    B3KUI3
    Related
    ENSP00000292067.7, ENST00000292067.11
    Conserved Domains (2) summary
    smart00410
    Location:187241
    IG_like; Immunoglobulin like
    pfam07686
    Location:16126
    V-set; Immunoglobulin V-set domain

RNA

  1. NR_104479.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two exons in the 5' region, contains an alternate 5' terminal exon, and uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK097285, AP002800, BC100795, BC100797

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    118193725..118225089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017214.1XP_016872703.1  junctional adhesion molecule-like isoform X3

    Conserved Domains (1) summary
    cl11960
    Location:45103
    Ig; Immunoglobulin domain
  2. XM_017017215.1XP_016872704.1  junctional adhesion molecule-like isoform X3

    Conserved Domains (1) summary
    cl11960
    Location:45103
    Ig; Immunoglobulin domain
  3. XM_017017213.1XP_016872702.1  junctional adhesion molecule-like isoform X1

  4. XM_024448351.1XP_024304119.1  junctional adhesion molecule-like isoform X3

    Conserved Domains (1) summary
    cl11960
    Location:45103
    Ig; Immunoglobulin domain
  5. XM_005271407.3XP_005271464.1  junctional adhesion molecule-like isoform X2

    Conserved Domains (2) summary
    smart00410
    Location:17125
    IG_like; Immunoglobulin like
    pfam07686
    Location:16126
    V-set; Immunoglobulin V-set domain

RNA

  1. XR_001747770.1 RNA Sequence

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