Format

Send to:

Choose Destination

Bcat2 branched chain aminotransferase 2, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 12036, updated on 19-Oct-2017
Official Symbol
Bcat2provided by MGI
Official Full Name
branched chain aminotransferase 2, mitochondrialprovided by MGI
Primary source
MGI:MGI:1276534
See related
Ensembl:ENSMUSG00000030826 Vega:OTTMUSG00000030313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eca40; Bcat-2; Bcat(m)
Expression
Ubiquitous expression in adrenal adult (RPKM 36.2), subcutaneous fat pad adult (RPKM 34.2) and 28 other tissues See more
Orthologs
Location:
7 B3; 7 29.36 cM
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (45569763..45589710)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (52825733..52845078)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 14 Neighboring gene RIKEN cDNA 0610005C13 gene Neighboring gene predicted gene, 31479 Neighboring gene fibroblast growth factor 21 Neighboring gene fucosyltransferase 1

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
L-isoleucine transaminase activity IEA
Inferred from Electronic Annotation
more info
 
L-leucine transaminase activity IEA
Inferred from Electronic Annotation
more info
 
L-valine transaminase activity IEA
Inferred from Electronic Annotation
more info
 
branched-chain-amino-acid transaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
branched-chain-amino-acid transaminase activity ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
transaminase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
branched-chain amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
branched-chain amino acid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
branched-chain amino acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
branched-chain amino acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
isoleucine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
isoleucine catabolic process ISO
Inferred from Sequence Orthology
more info
 
isoleucine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
leucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
leucine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
leucine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of hormone levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
valine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
valine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
branched-chain-amino-acid aminotransferase, mitochondrial
NP_001229981.1
NP_033867.1
XP_006540650.1
XP_017177442.1
XP_017177443.1
XP_017177444.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243052.1NP_001229981.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001229981.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AI327099, AK137049, AK160159
    Consensus CDS
    CCDS57549.1
    UniProtKB/TrEMBL
    O88374
    Related
    ENSMUSP00000148152.1, OTTMUSP00000039290, ENSMUST00000209204.1, OTTMUST00000075078
    Conserved Domains (2) summary
    PRK13357
    Location:1353
    PRK13357; branched-chain amino acid aminotransferase; Provisional
    cd01557
    Location:48343
    BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...
  2. NM_009737.3NP_033867.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_033867.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI327099, AK137049, BB630667, BY279029
    Consensus CDS
    CCDS21252.1
    UniProtKB/Swiss-Prot
    O35855
    UniProtKB/TrEMBL
    O88374, Q3ULU3
    Related
    ENSMUSP00000033098.7, OTTMUSP00000039289, ENSMUST00000033098.15, OTTMUST00000075076
    Conserved Domains (2) summary
    PRK13357
    Location:41393
    PRK13357; branched-chain amino acid aminotransferase; Provisional
    cd01557
    Location:88383
    BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    45569763..45589710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321955.1XP_017177444.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform X3

  2. XM_006540587.3XP_006540650.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform X4

    Conserved Domains (1) summary
    cl00224
    Location:88234
    PLPDE_IV; PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate ...
  3. XM_017321953.1XP_017177442.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform X1

  4. XM_017321954.1XP_017177443.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001243053.1: Suppressed sequence

    Description
    NM_001243053.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Support Center