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Phb2 prohibitin 2 [ Mus musculus (house mouse) ]

Gene ID: 12034, updated on 5-Feb-2023

Summary

Official Symbol
Phb2provided by MGI
Official Full Name
prohibitin 2provided by MGI
Primary source
MGI:MGI:102520
See related
Ensembl:ENSMUSG00000004264 AllianceGenome:MGI:102520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BAP; REA; Bap37; Bcap37
Summary
Enables sphingolipid binding activity. Involved in several processes, including CD40 signaling pathway; regulation of gene expression; and regulation of phosphate metabolic process. Acts upstream of or within several processes, including mammary gland development; negative regulation of intracellular estrogen receptor signaling pathway; and negative regulation of mammary gland epithelial cell proliferation. Located in cell surface; mitochondrial inner membrane; and nucleus. Part of inner mitochondrial membrane protein complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Orthologous to human PHB2 (prohibitin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 52.3), liver E14.5 (RPKM 50.9) and 28 other tissues See more
Orthologs
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Genomic context

See Phb2 in Genome Data Viewer
Location:
6 F2; 6 59.17 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124689252..124693908)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124712289..124716945)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene complement component 1, s subcomponent 2 Neighboring gene lysophosphatidylcholine acyltransferase 3 Neighboring gene EMG1 N1-specific pseudouridine methyltransferase Neighboring gene predicted gene, 23547 Neighboring gene microRNA 200c Neighboring gene microRNA 141

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (5) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amide binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables sphingolipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sphingolipid binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in CD40 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of intracellular estrogen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland branching involved in thelarche IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrion organization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of intracellular estrogen receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of intracellular estrogen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of exit from mitosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of immunoglobulin production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cardiolipin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytochrome-c oxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytochrome-c oxidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of inner mitochondrial membrane protein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial prohibitin complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of mitochondrial prohibitin complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
prohibitin-2
Names
B-cell receptor-associated protein 37
B-cell receptor-associated protein BAP37
repressor of estrogen receptor activity

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007531.2NP_031557.2  prohibitin-2

    See identical proteins and their annotated locations for NP_031557.2

    Status: VALIDATED

    Source sequence(s)
    AK002334, AK132058, AK152375, BB595613
    Consensus CDS
    CCDS39627.1
    UniProtKB/Swiss-Prot
    O35129, Q61336
    UniProtKB/TrEMBL
    A0A6P5PXB8, A0A8C6HF56, Q3V235
    Related
    ENSMUSP00000004375.10, ENSMUST00000004375.16
    Conserved Domains (1) summary
    cd03401
    Location:40235
    SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    124689252..124693908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)