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TMEM45B transmembrane protein 45B [ Homo sapiens (human) ]

Gene ID: 120224, updated on 1-Jun-2020

Summary

Official Symbol
TMEM45Bprovided by HGNC
Official Full Name
transmembrane protein 45Bprovided by HGNC
Primary source
HGNC:HGNC:25194
See related
Ensembl:ENSG00000151715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in duodenum (RPKM 57.4), small intestine (RPKM 54.1) and 9 other tissues See more
Orthologs

Genomic context

See TMEM45B in Genome Data Viewer
Location:
11q24.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (129815781..129860003)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (129685732..129729898)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27 pseudogene 20 Neighboring gene long intergenic non-protein coding RNA 1395 Neighboring gene TMEM45B-NFRKB intergenic CAGE-defined mid-level expression enhancer Neighboring gene nuclear factor related to kappaB binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association search for type 2 diabetes genes in African Americans.
NHGRI GWA Catalog
Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40787

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331210.1NP_001318139.1  transmembrane protein 45B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AP003327, BU607569, HY117153
    Consensus CDS
    CCDS8482.1
    UniProtKB/Swiss-Prot
    Q96B21
    Conserved Domains (1) summary
    pfam04819
    Location:117234
    DUF716; Family of unknown function (DUF716)
  2. NM_001331211.1NP_001318140.1  transmembrane protein 45B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AK098106, BU607569, HY117153
    Consensus CDS
    CCDS8482.1
    UniProtKB/Swiss-Prot
    Q96B21
    Related
    ENSP00000436293.1, ENST00000524567.1
    Conserved Domains (1) summary
    pfam04819
    Location:117234
    DUF716; Family of unknown function (DUF716)
  3. NM_001331212.1NP_001318141.1  transmembrane protein 45B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AK098106, BM762740, BU607569, HY117153
    Consensus CDS
    CCDS8482.1
    UniProtKB/Swiss-Prot
    Q96B21
    Conserved Domains (1) summary
    pfam04819
    Location:117234
    DUF716; Family of unknown function (DUF716)
  4. NM_138788.5NP_620143.1  transmembrane protein 45B

    See identical proteins and their annotated locations for NP_620143.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AK098106, AP003327, BU607569
    Consensus CDS
    CCDS8482.1
    UniProtKB/Swiss-Prot
    Q96B21
    Related
    ENSP00000281441.3, ENST00000281441.8
    Conserved Domains (1) summary
    pfam04819
    Location:117234
    DUF716; Family of unknown function (DUF716)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    129815781..129860003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017188.1XP_016872677.1  transmembrane protein 45B isoform X1

    UniProtKB/Swiss-Prot
    Q96B21
    Conserved Domains (1) summary
    pfam04819
    Location:117234
    DUF716; Family of unknown function (DUF716)
  2. XM_017017189.1XP_016872678.1  transmembrane protein 45B isoform X1

    UniProtKB/Swiss-Prot
    Q96B21
    Conserved Domains (1) summary
    pfam04819
    Location:117234
    DUF716; Family of unknown function (DUF716)
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