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Bach1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 12013, updated on 18-Sep-2024

Summary

Official Symbol
Bach1provided by MGI
Official Full Name
BTB and CNC homology 1, basic leucine zipper transcription factor 1provided by MGI
Primary source
MGI:MGI:894680
See related
Ensembl:ENSMUSG00000025612 AllianceGenome:MGI:894680
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6230421P05Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Orthologous to human BACH1 (BTB domain and CNC homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 12.9), large intestine adult (RPKM 9.3) and 27 other tissues See more
Orthologs
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Genomic context

See Bach1 in Genome Data Viewer
Location:
16 C3.3; 16 49.84 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (87495842..87530234)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (87698954..87733346)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41401 Neighboring gene predicted gene, 22808 Neighboring gene predicted gene, 53917 Neighboring gene STARR-seq mESC enhancer starr_41404 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:87709451-87709604 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:87723887-87724040 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:87727532-87727781 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:87729167-87729320 Neighboring gene predicted gene, 32925 Neighboring gene predicted gene, 23994 Neighboring gene RIKEN cDNA 2810407A14 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription regulator protein BACH1
Names
BTB and CNC homolog 1
BTB and CNC homology 1 transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007520.2NP_031546.1  transcription regulator protein BACH1

    See identical proteins and their annotated locations for NP_031546.1

    Status: VALIDATED

    Source sequence(s)
    AC164108, AK140903, AK141405
    Consensus CDS
    CCDS28293.1
    UniProtKB/Swiss-Prot
    P97302
    UniProtKB/TrEMBL
    Q3URL4, Q3US24
    Related
    ENSMUSP00000026703.6, ENSMUST00000026703.6
    Conserved Domains (2) summary
    cd14719
    Location:554624
    bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
    cd18277
    Location:7126
    BTB_POZ_BACH1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    87495842..87530234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248939.1XP_030104799.1  transcription regulator protein BACH1 isoform X2

    Conserved Domains (1) summary
    cd14719
    Location:272342
    bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
  2. XM_006522879.4XP_006522942.1  transcription regulator protein BACH1 isoform X1

    See identical proteins and their annotated locations for XP_006522942.1

    UniProtKB/Swiss-Prot
    P97302
    UniProtKB/TrEMBL
    Q3URL4, Q3US24
    Conserved Domains (2) summary
    cd14719
    Location:554624
    bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
    cd18277
    Location:7126
    BTB_POZ_BACH1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1)