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FAT3 FAT atypical cadherin 3 [ Homo sapiens (human) ]

Gene ID: 120114, updated on 31-Oct-2022

Summary

Official Symbol
FAT3provided by HGNC
Official Full Name
FAT atypical cadherin 3provided by HGNC
Primary source
HGNC:HGNC:23112
See related
Ensembl:ENSG00000165323 MIM:612483; AllianceGenome:HGNC:23112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hFat3; CDHF15; CDHR10
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within several processes, including negative regulation of dendrite development; neuron migration; and retina layer formation. Predicted to be located in dendrite and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 1.5), prostate (RPKM 0.4) and 7 other tissues See more
Orthologs
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Genomic context

See FAT3 in Genome Data Viewer
Location:
11q14.3
Exon count:
34
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (92224818..92896473)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (92147480..92825282)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (91957984..92629639)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369429 Neighboring gene ribosomal protein L7a pseudogene 57 Neighboring gene NADH:ubiquinone oxidoreductase subunit B11 pseudogene 1 Neighboring gene phosphoglycerate mutase 1 pseudogene 9 Neighboring gene RPS3A pseudogene 42 Neighboring gene uncharacterized LOC124902732 Neighboring gene small nucleolar RNA U13 Neighboring gene long intergenic non-protein coding RNA 2746 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 49 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
EBI GWAS Catalog
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30341, KIAA1989

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell morphogenesis involved in differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dendrite development IEA
Inferred from Electronic Annotation
more info
 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
involved_in interneuron migration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of dendrite development IEA
Inferred from Electronic Annotation
more info
 
involved_in retina layer formation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protocadherin Fat 3
Names
FAT tumor suppressor homolog 3
cadherin family member 15
cadherin-related family member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052813.1 RefSeqGene

    Range
    5183..676838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001008781.3NP_001008781.2  protocadherin Fat 3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AP000722, AP000805, AP002514, AP003124, AP003171, AP003718
    UniProtKB/Swiss-Prot
    Q8TDW7, Q96AU6
    Related
    ENSP00000387040.2, ENST00000409404.6
    Conserved Domains (4) summary
    cd11304
    Location:32413337
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:40234058
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:38653994
    Laminin_G_2; Laminin G domain
    cl29226
    Location:286357
    Cadherin; Cadherin domain
  2. NM_001367949.2NP_001354878.1  protocadherin Fat 3 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AP000722, AP000805, AP002514, AP003124, AP003171, AP003718
    Consensus CDS
    CCDS91573.1
    Related
    ENSP00000432586.2, ENST00000525166.6
  3. NM_001378141.1NP_001365070.1  protocadherin Fat 3 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AP000722, AP000805, AP002514, AP003124
    Conserved Domains (2) summary
    cd11304
    Location:10491144
    Cadherin_repeat; Cadherin tandem repeat domain
    cl29226
    Location:286357
    Cadherin; Cadherin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    92224818..92896473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017179.3XP_016872668.1  protocadherin Fat 3 isoform X1

  2. XM_017017178.3XP_016872667.1  protocadherin Fat 3 isoform X1

  3. XM_017017180.2XP_016872669.1  protocadherin Fat 3 isoform X2

  4. XM_017017182.3XP_016872671.1  protocadherin Fat 3 isoform X3

  5. XM_017017186.2XP_016872675.1  protocadherin Fat 3 isoform X6

  6. XM_017017184.3XP_016872673.1  protocadherin Fat 3 isoform X4

  7. XM_047426353.1XP_047282309.1  protocadherin Fat 3 isoform X1

  8. XM_017017187.2XP_016872676.1  protocadherin Fat 3 isoform X6

  9. XM_017017185.2XP_016872674.1  protocadherin Fat 3 isoform X5

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_013171808.1 Reference GRCh38.p14 PATCHES

    Range
    123862..157427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    92147480..92825282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)