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B2m beta-2 microglobulin [ Mus musculus (house mouse) ]

Gene ID: 12010, updated on 27-Feb-2024

Summary

Official Symbol
B2mprovided by MGI
Official Full Name
beta-2 microglobulinprovided by MGI
Primary source
MGI:MGI:88127
See related
Ensembl:ENSMUSG00000060802 AllianceGenome:MGI:88127
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly-m11; beta2m; beta2-m
Summary
Predicted to enable MHC class II protein complex binding activity and protein homodimerization activity. Involved in learning or memory; modulation of age-related behavioral decline; and negative regulation of cell differentiation. Acts upstream of or within several processes, including antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; cellular response to iron(III) ion; and protein refolding. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and retina. Used to study hemochromatosis and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in arthritis; familial visceral amyloidosis; immunodeficiency 43; and inflammatory bowel disease. Orthologous to human B2M (beta-2-microglobulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 838.6), mammary gland adult (RPKM 675.3) and 20 other tissues See more
Orthologs
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Genomic context

See B2m in Genome Data Viewer
Location:
2 E5; 2 60.55 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121978168..121983563)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122147687..122153082)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05545 Neighboring gene CTD small phosphatase like 2 Neighboring gene MAGE family member B3 Neighboring gene STARR-positive B cell enhancer ABC_E1597 Neighboring gene eukaryotic translation initiation factor 3, subunit J1 Neighboring gene SPG11, spatacsin vesicle trafficking associated Neighboring gene STARR-seq mESC enhancer starr_05546 Neighboring gene protein associated with topoisomerase II homolog 2 (yeast) Neighboring gene STARR-positive B cell enhancer ABC_E512 Neighboring gene STARR-seq mESC enhancer starr_05550 Neighboring gene tripartite motif-containing 69 Neighboring gene telomere repeat binding bouquet formation protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class II protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables structural molecule activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell differentiation in thymus IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I ISO
Inferred from Sequence Orthology
more info
 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of peptide antigen via MHC class I IEA
Inferred from Electronic Annotation
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular defense response TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to iron ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to iron(III) ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nicotine ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within iron ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of forebrain neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of forebrain neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of receptor binding ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide antigen assembly with MHC class I protein complex ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide antigen assembly with MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of T cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ferrous iron binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transferrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of iron ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to molecule of bacterial origin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of HFE-transferrin receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of MHC class I peptide loading complex ISO
Inferred from Sequence Orthology
more info
 
part_of MHC class I protein complex IEA
Inferred from Electronic Annotation
more info
 
part_of MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009735.3NP_033865.2  beta-2-microglobulin precursor

    See identical proteins and their annotated locations for NP_033865.2

    Status: VALIDATED

    Source sequence(s)
    AK019389
    Consensus CDS
    CCDS16654.1
    UniProtKB/Swiss-Prot
    P01887, Q91XJ8
    UniProtKB/TrEMBL
    Q3U679
    Related
    ENSMUSP00000099534.5, ENSMUST00000102476.5
    Conserved Domains (1) summary
    cd05770
    Location:23116
    IgC1_beta2m; Class I major histocompatibility complex (MHC) beta-2-microglobulin; member of the C1-set of Ig superfamily (IgSF) domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    121978168..121983563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)