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Axin2 axin 2 [ Mus musculus (house mouse) ]

Gene ID: 12006, updated on 17-Jan-2023

Summary

Official Symbol
Axin2provided by MGI
Official Full Name
axin 2provided by MGI
Primary source
MGI:MGI:1270862
See related
Ensembl:ENSMUSG00000000142 AllianceGenome:MGI:1270862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Axi1; Axil; Conductin
Summary
Enables I-SMAD binding activity and ubiquitin protein ligase binding activity. Involved in regulation of centromeric sister chromatid cohesion. Acts upstream of or within several processes, including animal organ development; negative regulation of osteoblast differentiation; and regulation of chondrocyte development. Located in centrosome and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study craniosynostosis. Human ortholog(s) of this gene implicated in colorectal cancer and endometrial adenocarcinoma. Orthologous to human AXIN2 (axin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 14.6), limb E14.5 (RPKM 12.0) and 22 other tissues See more
Orthologs
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Genomic context

See Axin2 in Genome Data Viewer
Location:
11 E1; 11 71.83 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (108808654..108841609)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (108917828..108950783)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 112 Neighboring gene centrosomal protein 112, intronic transcript Neighboring gene predicted gene, 36818 Neighboring gene predicted gene, 46298 Neighboring gene predicted gene, 36876 Neighboring gene predicted gene, 24149

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables I-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables I-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in aortic valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chondrocyte differentiation involved in endochondral bone morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intramembranous ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in maintenance of DNA repeat elements ISO
Inferred from Sequence Orthology
more info
 
involved_in mitral valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in odontogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of centromeric sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of centromeric sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of centromeric sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of chondrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mismatch repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within secondary heart field specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within somitogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of beta-catenin destruction complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of beta-catenin destruction complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
axin-2
Names
axin-like protein
axis inhibition protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015732.4NP_056547.3  axin-2

    See identical proteins and their annotated locations for NP_056547.3

    Status: VALIDATED

    Source sequence(s)
    AK142333, BC057338
    Consensus CDS
    CCDS25575.1
    UniProtKB/Swiss-Prot
    O88566, Q9QXJ6
    UniProtKB/TrEMBL
    Q3UQK5
    Related
    ENSMUSP00000051331.8, ENSMUST00000052915.14
    Conserved Domains (4) summary
    cd08707
    Location:82198
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    smart00021
    Location:758840
    DAX; Domain present in Dishevelled and axin
    pfam08833
    Location:432467
    Axin_b-cat_bind; Axin beta-catenin binding domain
    pfam16646
    Location:1073
    AXIN1_TNKS_BD; Axin-1 tankyrase binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    108808654..108841609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532058.2XP_006532121.1  axin-2 isoform X1

    See identical proteins and their annotated locations for XP_006532121.1

    UniProtKB/Swiss-Prot
    O88566, Q9QXJ6
    Conserved Domains (4) summary
    cd08707
    Location:82198
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    smart00021
    Location:758840
    DAX; Domain present in Dishevelled and axin
    pfam08833
    Location:432467
    Axin_b-cat_bind; Axin beta-catenin binding domain
    pfam16646
    Location:1073
    AXIN1_TNKS_BD; Axin-1 tankyrase binding domain
  2. XM_006532057.4XP_006532120.1  axin-2 isoform X1

    See identical proteins and their annotated locations for XP_006532120.1

    UniProtKB/Swiss-Prot
    O88566, Q9QXJ6
    Conserved Domains (4) summary
    cd08707
    Location:82198
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    smart00021
    Location:758840
    DAX; Domain present in Dishevelled and axin
    pfam08833
    Location:432467
    Axin_b-cat_bind; Axin beta-catenin binding domain
    pfam16646
    Location:1073
    AXIN1_TNKS_BD; Axin-1 tankyrase binding domain
  3. XM_006532060.3XP_006532123.1  axin-2 isoform X1

    See identical proteins and their annotated locations for XP_006532123.1

    UniProtKB/Swiss-Prot
    O88566, Q9QXJ6
    Related
    ENSMUSP00000102322.2, ENSMUST00000106711.2
    Conserved Domains (4) summary
    cd08707
    Location:82198
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    smart00021
    Location:758840
    DAX; Domain present in Dishevelled and axin
    pfam08833
    Location:432467
    Axin_b-cat_bind; Axin beta-catenin binding domain
    pfam16646
    Location:1073
    AXIN1_TNKS_BD; Axin-1 tankyrase binding domain
  4. XM_006532059.5XP_006532122.1  axin-2 isoform X1

    See identical proteins and their annotated locations for XP_006532122.1

    UniProtKB/Swiss-Prot
    O88566, Q9QXJ6
    Conserved Domains (4) summary
    cd08707
    Location:82198
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    smart00021
    Location:758840
    DAX; Domain present in Dishevelled and axin
    pfam08833
    Location:432467
    Axin_b-cat_bind; Axin beta-catenin binding domain
    pfam16646
    Location:1073
    AXIN1_TNKS_BD; Axin-1 tankyrase binding domain
  5. XM_030245493.2XP_030101353.1  axin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q9QXJ6
    Conserved Domains (4) summary
    cd08707
    Location:82198
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    smart00021
    Location:758840
    DAX; Domain present in Dishevelled and axin
    pfam08833
    Location:432467
    Axin_b-cat_bind; Axin beta-catenin binding domain
    pfam16646
    Location:1073
    AXIN1_TNKS_BD; Axin-1 tankyrase binding domain