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Atp6v0c ATPase, H+ transporting, lysosomal V0 subunit C [ Mus musculus (house mouse) ]

Gene ID: 11984, updated on 3-Dec-2024

Summary

Official Symbol
Atp6v0cprovided by MGI
Official Full Name
ATPase, H+ transporting, lysosomal V0 subunit Cprovided by MGI
Primary source
MGI:MGI:88116
See related
Ensembl:ENSMUSG00000024121 AllianceGenome:MGI:88116
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atpl; PL16; VATL; Vma3; Atp6c; Atp6l; Atp6c2; Atpl-rs1
Summary
Predicted to enable P-type proton-exporting transporter activity and ubiquitin protein ligase binding activity. Involved in synaptic vesicle lumen acidification. Part of proton-transporting V-type ATPase complex. Is expressed in several structures, including alimentary system; blastocyst; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 768.5), adrenal adult (RPKM 629.5) and 28 other tissues See more
Orthologs
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Genomic context

See Atp6v0c in Genome Data Viewer
Location:
17 A3.3; 17 12.29 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24382839..24388652, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24163865..24169678, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene 3-phosphoinositide dependent protein kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1935 Neighboring gene predicted gene, 33409 Neighboring gene STARR-seq mESC enhancer starr_42075 Neighboring gene amidohydrolase domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E8658 Neighboring gene TBC1 domain family, member 24 Neighboring gene STARR-seq mESC enhancer starr_42079 Neighboring gene STARR-positive B cell enhancer ABC_E2472 Neighboring gene netrin 3 Neighboring gene tubulin epsilon and delta complex 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables P-type proton-exporting transporter activity ISA
Inferred from Sequence Alignment
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
part_of proton-transporting V-type ATPase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proton-transporting V-type ATPase, V0 domain TAS
Traceable Author Statement
more info
PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
part_of vacuolar proton-transporting V-type ATPase complex TAS
Traceable Author Statement
more info
PubMed 
part_of vacuolar proton-transporting V-type ATPase, V0 domain ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
V-type proton ATPase 16 kDa proteolipid subunit c
Names
ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa
ATPase, H+ transporting, lysosomal 16kD, V0 subunit C
ATPase, H+ transporting, lysosomal 2
H(+)-ATPase (mvp)
V-ATPase 16 kDa proteolipid subunit
V-ATPase 16 kDa proteolipid subunit c
V-type proton ATPase 16 kDa proteolipid subunit
vacuolar proton pump 16 kDa proteolipid subunit
vacuolar proton pump 16 kDa proteolipid subunit c
NP_001348460.1
NP_001348461.1
NP_001348462.1
NP_001348463.1
NP_001348464.1
NP_033859.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361531.1NP_001348460.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BP769833, BY140472, CT010502
    Conserved Domains (2) summary
    TIGR01100
    Location:72177
    V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
    pfam00137
    Location:152211
    ATP-synt_C; ATP synthase subunit C
  2. NM_001361532.1NP_001348461.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    CT010502
    Consensus CDS
    CCDS28476.1
    UniProtKB/Swiss-Prot
    P63082, Q3TD69
    UniProtKB/TrEMBL
    A3KML5, Q3UK60, Q4KL27, Q5XK06, Q8C1D9
    Related
    ENSMUSP00000111059.2, ENSMUST00000098862.9
    Conserved Domains (2) summary
    TIGR01100
    Location:13118
    V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
    cd18176
    Location:86153
    ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
  3. NM_001361533.1NP_001348462.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4-6 all encode the same isoform (c).
    Source sequence(s)
    BY140472, CT010502
    UniProtKB/TrEMBL
    Q3UK60
    Conserved Domains (2) summary
    cd18176
    Location:59126
    ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
    cl00466
    Location:191
    ATP-synt_C; ATP synthase subunit C
  4. NM_001361534.1NP_001348463.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4-6 all encode the same isoform (c).
    Source sequence(s)
    CT010502
    UniProtKB/TrEMBL
    Q3UK60
    Conserved Domains (2) summary
    cd18176
    Location:59126
    ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
    cl00466
    Location:191
    ATP-synt_C; ATP synthase subunit C
  5. NM_001361535.1NP_001348464.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4-6 all encode the same isoform (c).
    Source sequence(s)
    BB873227, CT010502
    UniProtKB/TrEMBL
    Q3UK60
    Conserved Domains (2) summary
    cd18176
    Location:59126
    ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
    cl00466
    Location:191
    ATP-synt_C; ATP synthase subunit C
  6. NM_009729.4NP_033859.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform b

    See identical proteins and their annotated locations for NP_033859.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AK002570, BC050939, BY245103
    Consensus CDS
    CCDS28476.1
    UniProtKB/Swiss-Prot
    P63082, Q3TD69
    UniProtKB/TrEMBL
    A3KML5, Q3UK60, Q4KL27, Q5XK06, Q8C1D9
    Related
    ENSMUSP00000024932.6, ENSMUST00000024932.12
    Conserved Domains (2) summary
    TIGR01100
    Location:13118
    V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
    cd18176
    Location:86153
    ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24382839..24388652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)