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Atp6v0c ATPase, H+ transporting, lysosomal V0 subunit C [ Mus musculus (house mouse) ]

Gene ID: 11984, updated on 7-Apr-2025

Summary

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Official Symbol
Atp6v0cprovided by MGI
Official Full Name
ATPase, H+ transporting, lysosomal V0 subunit Cprovided by MGI
Primary source
MGI:MGI:88116
See related
Ensembl:ENSMUSG00000024121 AllianceGenome:MGI:88116
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atpl; PL16; VATL; Vma3; Atp6c; Atp6l; Atp6c2; Atpl-rs1
Summary
Predicted to enable P-type proton-exporting transporter activity and ubiquitin protein ligase binding activity. Involved in synaptic vesicle lumen acidification. Part of proton-transporting V-type ATPase complex. Is expressed in several structures, including alimentary system; blastocyst; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in kidney adult (RPKM 768.5), adrenal adult (RPKM 629.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Atp6v0c in Genome Data Viewer
Location:
17 A3.3; 17 12.29 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24382839..24388652, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24163865..24169678, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene 3-phosphoinositide dependent protein kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1935 Neighboring gene predicted gene, 33409 Neighboring gene STARR-seq mESC enhancer starr_42075 Neighboring gene amidohydrolase domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E8658 Neighboring gene TBC1 domain family, member 24 Neighboring gene STARR-seq mESC enhancer starr_42079 Neighboring gene STARR-positive B cell enhancer ABC_E2472 Neighboring gene netrin 3 Neighboring gene tubulin epsilon and delta complex 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning of cDNA encoding the 16 KDa subunit of vacuolar H(+)-ATPase from mouse cerebellum. Hanada H, et al. Biochem Biophys Res Commun, 1991 May 15. PMID 1828149
  2. Targeted disruption of the gene encoding the proteolipid subunit of mouse vacuolar H(+)-ATPase leads to early embryonic lethality. Inoue H, et al. Biochim Biophys Acta, 1999 Nov 10. PMID 10556625
  3. Acidic endomembrane organelles are required for mouse postimplantation development. Sun-Wada G, et al. Dev Biol, 2000 Dec 15. PMID 11112332
  4. High glucose disrupts autophagy lysosomal pathway in gingival epithelial cells via ATP6V0C. Huang X, et al. J Periodontol, 2020 May. PMID 31471894
  5. Mouse proton pump ATPase C subunit isoforms (C2-a and C2-b) specifically expressed in kidney and lung. Sun-Wada GH, et al. J Biol Chem, 2003 Nov 7. PMID 12947086

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs.
    Title: Impaired TFEB-mediated autophagy-lysosome fusion promotes tubular cell cycle G2/M arrest and renal fibrosis by suppressing ATP6V0C expression and interacting with SNAREs.
  2. Vacuolar-type proton ATPase is required for maintenance of apicobasal polarity of embryonic visceral endoderm.
    Title: Vacuolar-type proton ATPase is required for maintenance of apicobasal polarity of embryonic visceral endoderm.
  3. High glucose disrupts autophagy lysosomal pathway in gingival epithelial cells via ATP6V0C.
    Title: High glucose disrupts autophagy lysosomal pathway in gingival epithelial cells via ATP6V0C.
  4. Results show that inhibition of V-ATPase by archazolid reduces the activity of prometastatic proteases like cathepsin B in vitro and in vivo.
    Title: V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo.
  5. mapped three ATP6V0C genes (Atp6v0c, Atp6v0c-ps1 and Atp6voc-ps2) in the murine genome
    Title: Chromosomal localization of three vacuolar-H+ -ATPase 16 kDa subunit (ATP6V0C) genes in the murine genome.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables P-type proton-exporting transporter activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lysosomal lumen acidification TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of autophagic cell death ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle lumen acidification EXP
Inferred from Experiment
more info
 PubMed 
involved_in synaptic vesicle lumen acidification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle lumen acidification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vacuolar acidification TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
part_of proton-transporting V-type ATPase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proton-transporting V-type ATPase, V0 domain TAS
Traceable Author Statement
more info
 PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
part_of vacuolar proton-transporting V-type ATPase complex TAS
Traceable Author Statement
more info
 PubMed 
part_of vacuolar proton-transporting V-type ATPase, V0 domain ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
V-type proton ATPase 16 kDa proteolipid subunit c
Names
ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa
ATPase, H+ transporting, lysosomal 16kD, V0 subunit C
ATPase, H+ transporting, lysosomal 2
H(+)-ATPase (mvp)
V-ATPase 16 kDa proteolipid subunit
V-ATPase 16 kDa proteolipid subunit c
V-type proton ATPase 16 kDa proteolipid subunit
vacuolar proton pump 16 kDa proteolipid subunit
vacuolar proton pump 16 kDa proteolipid subunit c
NP_001348460.1
NP_001348461.1
NP_001348462.1
NP_001348463.1
NP_001348464.1
NP_033859.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361531.1 → NP_001348460.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BP769833, BY140472, CT010502
    Conserved Domains (2) summary
    TIGR01100
    Location:72 → 177
    V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
    pfam00137
    Location:152 → 211
    ATP-synt_C; ATP synthase subunit C

  2. NM_001361532.1 → NP_001348461.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    CT010502
    Consensus CDS
    CCDS28476.1
    UniProtKB/Swiss-Prot
    P23967, P63082, Q3TD69
    UniProtKB/TrEMBL
    A3KML5, Q3UK60, Q4KL27, Q5XK06, Q8C1D9
    Related
    ENSMUSP00000111059.2, ENSMUST00000098862.9
    Conserved Domains (2) summary
    TIGR01100
    Location:13 → 118
    V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
    cd18176
    Location:86 → 153
    ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins

  3. NM_001361533.1 → NP_001348462.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4-6 all encode the same isoform (c).
    Source sequence(s)
    BY140472, CT010502
    UniProtKB/TrEMBL
    Q3UK60
    Conserved Domains (2) summary
    cd18176
    Location:59 → 126
    ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
    cl00466
    Location:1 → 91
    ATP-synt_C; ATP synthase subunit C

  4. NM_001361534.1 → NP_001348463.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4-6 all encode the same isoform (c).
    Source sequence(s)
    CT010502
    UniProtKB/TrEMBL
    Q3UK60
    Conserved Domains (2) summary
    cd18176
    Location:59 → 126
    ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
    cl00466
    Location:1 → 91
    ATP-synt_C; ATP synthase subunit C

  5. NM_001361535.1 → NP_001348464.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4-6 all encode the same isoform (c).
    Source sequence(s)
    BB873227, CT010502
    UniProtKB/TrEMBL
    Q3UK60
    Conserved Domains (2) summary
    cd18176
    Location:59 → 126
    ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
    cl00466
    Location:1 → 91
    ATP-synt_C; ATP synthase subunit C

  6. NM_009729.4 → NP_033859.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform b

    See identical proteins and their annotated locations for NP_033859.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AK002570, BC050939, BY245103
    Consensus CDS
    CCDS28476.1
    UniProtKB/Swiss-Prot
    P23967, P63082, Q3TD69
    UniProtKB/TrEMBL
    A3KML5, Q3UK60, Q4KL27, Q5XK06, Q8C1D9
    Related
    ENSMUSP00000024932.6, ENSMUST00000024932.12
    Conserved Domains (2) summary
    TIGR01100
    Location:13 → 118
    V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
    cd18176
    Location:86 → 153
    ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24382839..24388652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63082.1 GenPept UniProtKB/Swiss-Prot:P63082

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