U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Atp10a ATPase, class V, type 10A [ Mus musculus (house mouse) ]

Gene ID: 11982, updated on 26-Sep-2022

Summary

Official Symbol
Atp10aprovided by MGI
Official Full Name
ATPase, class V, type 10Aprovided by MGI
Primary source
MGI:MGI:1330809
See related
Ensembl:ENSMUSG00000025324 AllianceGenome:MGI:1330809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
pfatp; Atp10c
Summary
Predicted to enable glycosylceramide flippase activity and phosphatidylcholine flippase activity. Predicted to be involved in phospholipid translocation and positive regulation of membrane tubulation. Predicted to act upstream of or within lipid transport. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of plasma membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; brain; dorsal grey horn; lung; and testis. Orthologous to human ATP10A (ATPase phospholipid transporting 10A (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 15.3), adrenal adult (RPKM 11.8) and 18 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Atp10a in Genome Data Viewer
Location:
7; 7 B5
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (58305896..58479783)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (58656142..58830244)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26288 Neighboring gene nuclear encoded tRNA glutamic acid 7 (anticodon TTC) Neighboring gene predicted gene, 39019 Neighboring gene non-catalytic region of tyrosine kinase adaptor protein 2 pseudogene Neighboring gene crumbs homolog 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glycosylceramide flippase activity ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylcholine flippase activity ISO
Inferred from Sequence Orthology
more info
 
enables transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of membrane tubulation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phospholipid-transporting ATPase VA; probable phospholipid-transporting ATPase VA
Names
ATPase 10A, class V
ATPase, class 5
P-locus fat-associated ATPase
P4-ATPase flippase complex alpha subunit ATP10A
NP_033858.2
XP_006540643.1
XP_006540644.1
XP_006540646.1
XP_017177441.1
XP_036008505.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009728.2NP_033858.2  phospholipid-transporting ATPase VA

    See identical proteins and their annotated locations for NP_033858.2

    Status: VALIDATED

    Source sequence(s)
    AC163271, AK132174, AK172972, AV273066
    Consensus CDS
    CCDS39972.1
    UniProtKB/Swiss-Prot
    O54827, Q8R3B8
    UniProtKB/TrEMBL
    Q3V1Y7, Q6A046
    Related
    ENSMUSP00000129811.2, ENSMUST00000168747.3
    Conserved Domains (1) summary
    cd02073
    Location:651203
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    58305896..58479783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540581.4XP_006540644.1  probable phospholipid-transporting ATPase VA isoform X1

    See identical proteins and their annotated locations for XP_006540644.1

    UniProtKB/Swiss-Prot
    O54827, Q8R3B8
    UniProtKB/TrEMBL
    Q3V1Y7
    Conserved Domains (1) summary
    cd02073
    Location:651203
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  2. XM_006540580.4XP_006540643.1  probable phospholipid-transporting ATPase VA isoform X1

    See identical proteins and their annotated locations for XP_006540643.1

    UniProtKB/Swiss-Prot
    O54827, Q8R3B8
    UniProtKB/TrEMBL
    Q3V1Y7
    Conserved Domains (1) summary
    cd02073
    Location:651203
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  3. XM_036152612.1XP_036008505.1  probable phospholipid-transporting ATPase VA isoform X2

    Conserved Domains (1) summary
    cl21460
    Location:2876
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  4. XM_006540583.5XP_006540646.1  probable phospholipid-transporting ATPase VA isoform X4

    Conserved Domains (1) summary
    cd02073
    Location:258763
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  5. XM_017321952.3XP_017177441.1  probable phospholipid-transporting ATPase VA isoform X3

    Conserved Domains (1) summary
    cd02073
    Location:1835
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RNA

  1. XR_882009.3 RNA Sequence