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Atp8a1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 [ Mus musculus (house mouse) ]

Gene ID: 11980, updated on 9-Mar-2023

Summary

Official Symbol
Atp8a1provided by MGI
Official Full Name
ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1provided by MGI
Primary source
MGI:MGI:1330848
See related
Ensembl:ENSMUSG00000037685 AllianceGenome:MGI:1330848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APLT; Atp3a2; ClassI; B230107D19Rik
Summary
Enables phosphatidylserine flippase activity. Involved in learning; positive regulation of cell migration; and regulation of membrane lipid distribution. Located in cytoplasmic vesicle and organelle membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ATP8A1 (ATPase phospholipid transporting 8A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 16.4), cortex adult (RPKM 15.1) and 26 other tissues See more
Orthologs
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Genomic context

See Atp8a1 in Genome Data Viewer
Location:
5; 5 C3.1
Exon count:
39
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (67775482..68004822, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (67618139..67847484, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C330024D21 gene Neighboring gene CRISPRi-validated cis-regulatory element for Bend4 and Bendr Neighboring gene shisa family member 3 Neighboring gene predicted gene 15478 Neighboring gene predicted gene, 46914 Neighboring gene predicted gene, 52816 Neighboring gene predicted gene 15477 Neighboring gene RIKEN cDNA 4930425K10 gene Neighboring gene predicted gene 5108

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4233

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylserine flippase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphatidylserine flippase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in aminophospholipid translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aminophospholipid translocation ISO
Inferred from Sequence Orthology
more info
 
involved_in learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phospholipid translocation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in organelle membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phospholipid-transporting ATPase IA
Names
ATPase 8A1, aminophospholipid transporter (APLT), class I
ATPase 8A1, p type
ATPase class I type 8A member 1
P4-ATPase flippase complex alpha subunit ATP8A1
chromaffin granule ATPase II
probable phospholipid-transporting ATPase IA
NP_001034088.1
NP_001271274.1
NP_033857.1
XP_006503766.1
XP_011239000.1
XP_017176112.1
XP_017176113.1
XP_036020643.1
XP_036020644.1
XP_036020645.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038999.2NP_001034088.1  phospholipid-transporting ATPase IA isoform a

    See identical proteins and their annotated locations for NP_001034088.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform a.
    Source sequence(s)
    AC123662, AK045367, AK151709, BC094235
    Consensus CDS
    CCDS39104.1
    UniProtKB/Swiss-Prot
    P70704, Q8BR88
    UniProtKB/TrEMBL
    Q3U9N5, Q52KQ7
    Related
    ENSMUSP00000042215.9, ENSMUST00000037380.15
    Conserved Domains (6) summary
    TIGR01652
    Location:491086
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:106191
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:486581
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:38100
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:8271079
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:796825
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  2. NM_001284345.1NP_001271274.1  phospholipid-transporting ATPase IA isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and contains a different alternate exon in the 5' coding region, compared to variant 1. It encodes isoform c, which is of the same size but lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC123662, AK045367, AK141559, AK151709, BC094235
    Consensus CDS
    CCDS80295.1
    UniProtKB/Swiss-Prot
    P70704
    UniProtKB/TrEMBL
    A0A0M3HEP7, A0A8C6GN25, Q3U9N5, Q52KQ7
    Related
    ENSMUSP00000072738.8, ENSMUST00000072971.13
    Conserved Domains (6) summary
    TIGR01652
    Location:491086
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:106191
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:486581
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:38100
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:8271079
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:796825
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  3. NM_009727.3NP_033857.1  phospholipid-transporting ATPase IA isoform b

    See identical proteins and their annotated locations for NP_033857.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon and lacks two other alternate exons in the 5' coding region, compared to variant 1. It encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    AC123662, AK039919, AK045367, AK141559, AK151709, BC094235
    Consensus CDS
    CCDS39105.1
    UniProtKB/Swiss-Prot
    P70704
    UniProtKB/TrEMBL
    Q3U9N5, Q52KQ7, Q8CA15
    Related
    ENSMUSP00000118379.3, ENSMUST00000135930.8
    Conserved Domains (6) summary
    TIGR01652
    Location:491071
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:106191
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:471566
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:38100
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:8121064
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:781810
    HAD_like; Haloacid Dehalogenase-like Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    67775482..68004822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503703.5XP_006503766.1  phospholipid-transporting ATPase IA isoform X5

    See identical proteins and their annotated locations for XP_006503766.1

    Conserved Domains (1) summary
    TIGR01652
    Location:11922
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
  2. XM_036164750.1XP_036020643.1  phospholipid-transporting ATPase IA isoform X4

    Conserved Domains (1) summary
    TIGR01652
    Location:491071
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
  3. XM_011240698.4XP_011239000.1  phospholipid-transporting ATPase IA isoform X3

    Conserved Domains (1) summary
    TIGR01652
    Location:491096
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
  4. XM_036164751.1XP_036020644.1  phospholipid-transporting ATPase IA isoform X6

    Conserved Domains (1) summary
    TIGR01652
    Location:1907
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
  5. XM_017320623.3XP_017176112.1  phospholipid-transporting ATPase IA isoform X1

    Conserved Domains (1) summary
    TIGR01652
    Location:621099
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
  6. XM_017320624.3XP_017176113.1  phospholipid-transporting ATPase IA isoform X2

    Conserved Domains (1) summary
    TIGR01652
    Location:621084
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
  7. XM_036164752.1XP_036020645.1  phospholipid-transporting ATPase IA isoform X7

    Conserved Domains (1) summary
    TIGR01652
    Location:1707
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase