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IFTAP intraflagellar transport associated protein [ Homo sapiens (human) ]

Gene ID: 119710, updated on 18-Nov-2019

Summary

Official Symbol
IFTAPprovided by HGNC
Official Full Name
intraflagellar transport associated proteinprovided by HGNC
Primary source
HGNC:HGNC:25142
See related
Ensembl:ENSG00000166352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NWC; HEPIS; C11orf74
Summary
This gene encodes a protein that was identified as a cellular interacting partner of non-structural protein 10 of the severe acute respiratory syndrome coronavirus (SARS-CoV). The encoded protein may function as a negative regulator of transcription. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Expression
Broad expression in thyroid (RPKM 26.2), testis (RPKM 16.8) and 22 other tissues See more
Orthologs

Genomic context

See IFTAP in Genome Data Viewer
Location:
11p12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (36594246..36659291)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (36616043..36680841)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene TNF receptor associated factor 6 Neighboring gene recombination activating 1 Neighboring gene recombination activating 2 Neighboring gene uncharacterized LOC107984325 Neighboring gene transforming acidic coiled-coil containing protein 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38678

Gene Ontology Provided by GOA

Function Evidence Code Pubs
intraciliary transport particle A binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acrosome reaction IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
9+0 non-motile cilium IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein C11orf74
Names
uncharacterized protein C11orf74

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033154.1 RefSeqGene

    Range
    5001..69799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276722.1NP_001263651.1  protein C11orf74 isoform a

    See identical proteins and their annotated locations for NP_001263651.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, 3, and 4 encode the same isoform (a).
    Source sequence(s)
    AC139427, BC051031, BM670168, CD678640
    Consensus CDS
    CCDS7904.1
    UniProtKB/Swiss-Prot
    Q86VG3
    Related
    ENSP00000403937.3, ENST00000446510.6
  2. NM_001276723.1NP_001263652.1  protein C11orf74 isoform a

    See identical proteins and their annotated locations for NP_001263652.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).
    Source sequence(s)
    AC139427, BM670168, CD101968
    Consensus CDS
    CCDS7904.1
    UniProtKB/Swiss-Prot
    Q86VG3
    Related
    ENSP00000433407.2, ENST00000531554.6
  3. NM_001276724.1NP_001263653.1  protein C11orf74 isoform a

    See identical proteins and their annotated locations for NP_001263653.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).
    Source sequence(s)
    AC139427, BC051031, BI831382, BM670168, HY051439
    Consensus CDS
    CCDS7904.1
    UniProtKB/Swiss-Prot
    Q86VG3
    Related
    ENSP00000483671.1, ENST00000617650.4
  4. NM_001276725.1NP_001263654.1  protein C11orf74 isoform b

    See identical proteins and their annotated locations for NP_001263654.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 5, 6, and 7 encode the same isoform (b).
    Source sequence(s)
    AC139427, BM670168, BQ018679
    Consensus CDS
    CCDS60762.1
    UniProtKB/Swiss-Prot
    Q86VG3
    Related
    ENSP00000433152.1, ENST00000534635.5
  5. NM_001276726.1NP_001263655.1  protein C11orf74 isoform b

    See identical proteins and their annotated locations for NP_001263655.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in the 5' UTR and lacks two in-frame exons, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 5, 6, and 7 encode the same isoform (b).
    Source sequence(s)
    AC139427, BM670168, CD674194
    Consensus CDS
    CCDS60762.1
    UniProtKB/Swiss-Prot
    Q86VG3
  6. NM_001276727.1NP_001263656.1  protein C11orf74 isoform b

    See identical proteins and their annotated locations for NP_001263656.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in the 5' UTR and lacks two in-frame exons, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 5, 6, and 7 encode the same isoform (b).
    Source sequence(s)
    AC139427, BM670168, DQ121386
    Consensus CDS
    CCDS60762.1
    UniProtKB/Swiss-Prot
    Q86VG3
    Related
    ENSP00000299442.6, ENST00000347206.8
  7. NM_138787.3NP_620142.2  protein C11orf74 isoform a

    See identical proteins and their annotated locations for NP_620142.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).
    Source sequence(s)
    AC139427, AK290833, BC051031, BM670168
    Consensus CDS
    CCDS7904.1
    UniProtKB/Swiss-Prot
    Q86VG3
    UniProtKB/TrEMBL
    A8K468
    Related
    ENSP00000334848.5, ENST00000334307.9

RNA

  1. NR_077243.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use start codon used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC139427, AK302634, BM670168
    Related
    ENST00000528092.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    36594246..36659291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519885.3XP_011518187.1  protein C11orf74 isoform X1

    See identical proteins and their annotated locations for XP_011518187.1

    UniProtKB/Swiss-Prot
    Q86VG3
  2. XM_006718138.4XP_006718201.1  protein C11orf74 isoform X1

    See identical proteins and their annotated locations for XP_006718201.1

    UniProtKB/Swiss-Prot
    Q86VG3
    Related
    ENSP00000431374.2, ENST00000532470.2
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