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CPXM2 carboxypeptidase X, M14 family member 2 [ Homo sapiens (human) ]

Gene ID: 119587, updated on 24-Nov-2020

Summary

Official Symbol
CPXM2provided by HGNC
Official Full Name
carboxypeptidase X, M14 family member 2provided by HGNC
Primary source
HGNC:HGNC:26977
See related
Ensembl:ENSG00000121898 MIM:617348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPX2; UNQ676
Expression
Broad expression in urinary bladder (RPKM 10.5), fat (RPKM 8.3) and 19 other tissues See more
Orthologs

Genomic context

See CPXM2 in Genome Data Viewer
Location:
10q26.13
Exon count:
21
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (123745636..123944094, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (125505152..125651500, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 26 Neighboring gene uncharacterized LOC105378532 Neighboring gene uncharacterized LOC105378533 Neighboring gene uncharacterized LOC105378534 Neighboring gene uncharacterized LOC107984128 Neighboring gene uncharacterized LOC107984276 Neighboring gene YBX2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
GeneReviews: Not available
Genome-wide association study of smoking behaviours in patients with COPD.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
inactive carboxypeptidase-like protein X2
Names
4632435C11Rik
carboxypeptidase Hlo
carboxypeptidase X (M14 family), member 2
carboxypeptidase-like protein X2
cytosolic carboxypeptidase

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052814.1 RefSeqGene

    Range
    57288..203456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_198148.3NP_937791.2  inactive carboxypeptidase-like protein X2 precursor

    See identical proteins and their annotated locations for NP_937791.2

    Status: VALIDATED

    Source sequence(s)
    AC009987, AY358565
    Consensus CDS
    CCDS7637.1
    UniProtKB/Swiss-Prot
    Q8N436
    Related
    ENSP00000241305.3, ENST00000241305.4
    Conserved Domains (4) summary
    cd03869
    Location:314639
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:643718
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:138293
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:137292
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    123745636..123944094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015673.1XP_016871162.1  inactive carboxypeptidase-like protein X2 isoform X3

    Conserved Domains (4) summary
    cd03869
    Location:205530
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:534609
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:29184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:28183
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  2. XM_011539285.2XP_011537587.1  inactive carboxypeptidase-like protein X2 isoform X3

    Conserved Domains (4) summary
    cd03869
    Location:205530
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:534609
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:29184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:28183
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  3. XM_011539286.1XP_011537588.1  inactive carboxypeptidase-like protein X2 isoform X4

    Conserved Domains (4) summary
    cd03869
    Location:87412
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:416491
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:166
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:165
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  4. XM_017015674.1XP_016871163.1  inactive carboxypeptidase-like protein X2 isoform X5

  5. XM_011539283.2XP_011537585.1  inactive carboxypeptidase-like protein X2 isoform X2

    Conserved Domains (4) summary
    cd03869
    Location:314639
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    smart00231
    Location:138293
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:137292
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21470
    Location:643674
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
  6. XM_005269528.3XP_005269585.1  inactive carboxypeptidase-like protein X2 isoform X1

    Conserved Domains (4) summary
    cd03869
    Location:314639
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:643678
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:138293
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:137292
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
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