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ANAPC16 anaphase promoting complex subunit 16 [ Homo sapiens (human) ]

Gene ID: 119504, updated on 24-Nov-2020

Summary

Official Symbol
ANAPC16provided by HGNC
Official Full Name
anaphase promoting complex subunit 16provided by HGNC
Primary source
HGNC:HGNC:26976
See related
Ensembl:ENSG00000166295 MIM:613427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSAG; APC16; CENP-27; C10orf104; bA570G20.3
Expression
Ubiquitous expression in heart (RPKM 31.6), thyroid (RPKM 26.9) and 25 other tissues See more
Orthologs

Genomic context

See ANAPC16 in Genome Data Viewer
Location:
10q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (72216012..72235860)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (73975758..73995618)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 Neighboring gene activating signal cointegrator 1 complex subunit 1 Neighboring gene ribosomal protein L15 pseudogene 14 Neighboring gene DNA damage inducible transcript 4 Neighboring gene Sharpr-MPRA regulatory region 14427

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33728

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
anaphase-promoting complex subunit 16
Names
centromere protein 27
cyclosome subunit 16
metabolic syndrome-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242546.2NP_001229475.1  anaphase-promoting complex subunit 16 isoform 1

    See identical proteins and their annotated locations for NP_001229475.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Variants 1-3 encode the same protein (isoform 1).
    Source sequence(s)
    AL607035, CD724246, DA739927
    Consensus CDS
    CCDS7314.1
    UniProtKB/Swiss-Prot
    Q96DE5
    UniProtKB/TrEMBL
    C5H3H2
    Related
    ENSP00000477760.1, ENST00000621663.4
    Conserved Domains (1) summary
    pfam17256
    Location:27106
    ANAPC16; Anaphase Promoting Complex Subunit 16
  2. NM_001242547.2NP_001229476.1  anaphase-promoting complex subunit 16 isoform 1

    See identical proteins and their annotated locations for NP_001229476.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-3 encode the same protein (isoform 1).
    Source sequence(s)
    AL607035, CD511334, CD724246
    Consensus CDS
    CCDS7314.1
    UniProtKB/Swiss-Prot
    Q96DE5
    UniProtKB/TrEMBL
    C5H3H2
    Conserved Domains (1) summary
    pfam17256
    Location:27106
    ANAPC16; Anaphase Promoting Complex Subunit 16
  3. NM_001242548.2NP_001229477.1  anaphase-promoting complex subunit 16 isoform 2

    See identical proteins and their annotated locations for NP_001229477.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL607035, CB984695, CD724246, DA739927
    Consensus CDS
    CCDS73147.1
    UniProtKB/TrEMBL
    A0A087WUN5
    Related
    ENSP00000478792.1, ENST00000615507.4
    Conserved Domains (1) summary
    pfam17256
    Location:2781
    ANAPC16; Anaphase Promoting Complex Subunit 16
  4. NM_001366791.1NP_001353720.1  anaphase-promoting complex subunit 16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL607035
    Conserved Domains (1) summary
    pfam17256
    Location:27106
    ANAPC16; Anaphase Promoting Complex Subunit 16
  5. NM_173473.4NP_775744.1  anaphase-promoting complex subunit 16 isoform 1

    See identical proteins and their annotated locations for NP_775744.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-3 encode the same protein (isoform 1).
    Source sequence(s)
    AL607035, CD724246, DA739927
    Consensus CDS
    CCDS7314.1
    UniProtKB/Swiss-Prot
    Q96DE5
    UniProtKB/TrEMBL
    C5H3H2
    Related
    ENSP00000299381.3, ENST00000299381.5
    Conserved Domains (1) summary
    pfam17256
    Location:27106
    ANAPC16; Anaphase Promoting Complex Subunit 16

RNA

  1. NR_038391.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks multiple exons at the 5' end, compared to variant 1, which results in the loss of the start codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated.
    Source sequence(s)
    AL607035, CD724246, DA310509
  2. NR_038392.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks multiple exons at the 5' end, compared to variant 1, which results in the loss of the start codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated.
    Source sequence(s)
    AL607035, BM768948, CD724246, DA739927

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    72216012..72235860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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