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ANAPC16 anaphase promoting complex subunit 16 [ Homo sapiens (human) ]

Gene ID: 119504, updated on 27-Nov-2024

Summary

Official Symbol
ANAPC16provided by HGNC
Official Full Name
anaphase promoting complex subunit 16provided by HGNC
Primary source
HGNC:HGNC:26976
See related
Ensembl:ENSG00000166295 MIM:613427; AllianceGenome:HGNC:26976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSAG; APC16; CENP-27; C10orf104; bA570G20.3
Summary
Involved in anaphase-promoting complex-dependent catabolic process and protein polyubiquitination. Located in cytosol and kinetochore. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart (RPKM 31.6), thyroid (RPKM 26.9) and 25 other tissues See more
Orthologs
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Genomic context

See ANAPC16 in Genome Data Viewer
Location:
10q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (72216012..72235860)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (73087082..73106898)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (73975770..73995618)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene activating signal cointegrator 1 complex subunit 1 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene ReSE screen-validated silencer GRCh37_chr10:73950125-73950295 Neighboring gene ribosomal protein L15 pseudogene 14 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:73973271-73973772 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:73973773-73974272 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73975455-73976450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73977030-73977571 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3529 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74007658-74008225 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74008226-74008794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74008795-74009361 Neighboring gene Sharpr-MPRA regulatory region 8691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3533 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74020023-74020666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3535 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:74030210-74030710 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:74030711-74031211 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74032179-74032702 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74032703-74033226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:74035325-74035848 Neighboring gene DDIT4 antisense RNA 1 Neighboring gene DNA damage inducible transcript 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ33728

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of anaphase-promoting complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of anaphase-promoting complex NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
anaphase-promoting complex subunit 16
Names
centromere protein 27
cyclosome subunit 16
metabolic syndrome-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242546.2NP_001229475.1  anaphase-promoting complex subunit 16 isoform 1

    See identical proteins and their annotated locations for NP_001229475.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Variants 1-3 encode the same protein (isoform 1).
    Source sequence(s)
    AL607035, CD724246, DA739927
    Consensus CDS
    CCDS7314.1
    UniProtKB/Swiss-Prot
    Q96DE5
    UniProtKB/TrEMBL
    C5H3H2
    Related
    ENSP00000477760.1, ENST00000621663.4
    Conserved Domains (1) summary
    pfam17256
    Location:27106
    ANAPC16; Anaphase Promoting Complex Subunit 16
  2. NM_001242547.2NP_001229476.1  anaphase-promoting complex subunit 16 isoform 1

    See identical proteins and their annotated locations for NP_001229476.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-3 encode the same protein (isoform 1).
    Source sequence(s)
    AL607035, CD511334, CD724246
    Consensus CDS
    CCDS7314.1
    UniProtKB/Swiss-Prot
    Q96DE5
    UniProtKB/TrEMBL
    C5H3H2
    Conserved Domains (1) summary
    pfam17256
    Location:27106
    ANAPC16; Anaphase Promoting Complex Subunit 16
  3. NM_001242548.2NP_001229477.1  anaphase-promoting complex subunit 16 isoform 2

    See identical proteins and their annotated locations for NP_001229477.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL607035, CB984695, CD724246, DA739927
    Consensus CDS
    CCDS73147.1
    UniProtKB/TrEMBL
    A0A087WUN5
    Related
    ENSP00000478792.1, ENST00000615507.4
    Conserved Domains (1) summary
    pfam17256
    Location:2781
    ANAPC16; Anaphase Promoting Complex Subunit 16
  4. NM_001366791.1NP_001353720.1  anaphase-promoting complex subunit 16 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL607035
    Consensus CDS
    CCDS7314.1
    UniProtKB/Swiss-Prot
    Q96DE5
    UniProtKB/TrEMBL
    C5H3H2
    Conserved Domains (1) summary
    pfam17256
    Location:27106
    ANAPC16; Anaphase Promoting Complex Subunit 16
  5. NM_173473.4NP_775744.1  anaphase-promoting complex subunit 16 isoform 1

    See identical proteins and their annotated locations for NP_775744.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-3 encode the same protein (isoform 1).
    Source sequence(s)
    AL607035, CD724246, DA739927
    Consensus CDS
    CCDS7314.1
    UniProtKB/Swiss-Prot
    Q96DE5
    UniProtKB/TrEMBL
    C5H3H2
    Related
    ENSP00000299381.3, ENST00000299381.5
    Conserved Domains (1) summary
    pfam17256
    Location:27106
    ANAPC16; Anaphase Promoting Complex Subunit 16

RNA

  1. NR_038391.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks multiple exons at the 5' end, compared to variant 1, which results in the loss of the start codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated.
    Source sequence(s)
    AL607035, CD724246, DA310509
  2. NR_038392.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks multiple exons at the 5' end, compared to variant 1, which results in the loss of the start codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated.
    Source sequence(s)
    AL607035, BM768948, CD724246, DA739927

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    72216012..72235860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424580.1XP_047280536.1  anaphase-promoting complex subunit 16 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE5
    UniProtKB/TrEMBL
    C5H3H2
  2. XM_047424582.1XP_047280538.1  anaphase-promoting complex subunit 16 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE5
    UniProtKB/TrEMBL
    C5H3H2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    73087082..73106898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364752.1XP_054220727.1  anaphase-promoting complex subunit 16 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE5
    UniProtKB/TrEMBL
    C5H3H2
  2. XM_054364753.1XP_054220728.1  anaphase-promoting complex subunit 16 isoform X1

    UniProtKB/Swiss-Prot
    Q96DE5
    UniProtKB/TrEMBL
    C5H3H2