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Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 11946, updated on 11-Aug-2022

Summary

Official Symbol
Atp5a1provided by MGI
Official Full Name
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1provided by MGI
Primary source
MGI:MGI:88115
See related
Ensembl:ENSMUSG00000025428 AllianceGenome:MGI:88115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atpm; Mom2; Atp5f1a; AI035633; AL022851; AL023067; D18Ertd206e
Summary
Enables ATP binding activity and proton-transporting ATP synthase activity, rotational mechanism. Acts upstream of or within lipid metabolic process. Located in membrane and mitochondrion. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 22 and mitochondrial complex V (ATP synthase) deficiency nuclear type 4. Orthologous to human ATP5F1A (ATP synthase F1 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 1425.7), kidney adult (RPKM 741.8) and 28 other tissues See more
Orthologs
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Genomic context

See Atp5a1 in Genome Data Viewer
Location:
18 E3; 18 52.38 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (77861468..77870569)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (77773768..77782869)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (78012507..78021608)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5730552O08 gene Neighboring gene HAUS augmin-like complex, subunit 1 Neighboring gene predicted gene, 52331 Neighboring gene RIKEN cDNA F830208F22 gene Neighboring gene proline-serine-threonine phosphatase-interacting protein 2 Neighboring gene ectopic P-granules autophagy protein 5 homolog (C. elegans)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ADP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables MHC class I protein binding ISO
Inferred from Sequence Orthology
more info
 
enables adenyl ribonucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables angiostatin binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables proton-transporting ATP synthase activity, rotational mechanism IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
 
enables proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial proton-transporting ATP synthase, catalytic core IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
 
part_of proton-transporting ATP synthase complex, catalytic core F(1) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proton-transporting ATP synthase complex, catalytic core F(1) ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP synthase subunit alpha, mitochondrial
Names
ATP synthase F1 subunit alpha
modifier of Min 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007505.2NP_031531.1  ATP synthase subunit alpha, mitochondrial precursor

    See identical proteins and their annotated locations for NP_031531.1

    Status: VALIDATED

    Source sequence(s)
    AK159540, BY465601, CJ155200
    Consensus CDS
    CCDS29358.1
    UniProtKB/Swiss-Prot
    Q03265, Q543Y6
    Related
    ENSMUSP00000026495.9, ENSMUST00000026495.15
    Conserved Domains (4) summary
    PRK09281
    Location:49553
    PRK09281; F0F1 ATP synthase subunit alpha; Validated
    cd01132
    Location:137418
    F1_ATPase_alpha; F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to ...
    pfam00306
    Location:427518
    ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain
    pfam02874
    Location:69135
    ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    77861468..77870569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)