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SFR1 SWI5 dependent homologous recombination repair protein 1 [ Homo sapiens (human) ]

Gene ID: 119392, updated on 11-Jun-2021

Summary

Official Symbol
SFR1provided by HGNC
Official Full Name
SWI5 dependent homologous recombination repair protein 1provided by HGNC
Primary source
HGNC:HGNC:29574
See related
Ensembl:ENSG00000156384 MIM:616527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEI5; MEIR5; C10orf78; bA373N18.1
Expression
Broad expression in testis (RPKM 6.8), appendix (RPKM 2.8) and 25 other tissues See more
Orthologs
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Genomic context

See SFR1 in Genome Data Viewer
Location:
10q25.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (104120166..104126385)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (105879924..105886141)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 524, pseudogene Neighboring gene STE20 like kinase Neighboring gene collagen type XVII alpha 1 chain Neighboring gene microRNA 936 Neighboring gene cilia and flagella associated protein 43 Neighboring gene tropomyosin 3 pseudogene Neighboring gene microRNA 609

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41960

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Swi5-Sfr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Swi5-Sfr1 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
swi5-dependent recombination DNA repair protein 1 homolog
Names
MEI5 recombination repair protein homolog
SWI5-dependent recombination repair 1
SWI5-dependent recombination repair protein 1
meiosis protein 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002759.2NP_001002759.1  swi5-dependent recombination DNA repair protein 1 homolog isoform a

    See identical proteins and their annotated locations for NP_001002759.1

    Status: VALIDATED

    Source sequence(s)
    AL357336
    Consensus CDS
    CCDS31279.1
    UniProtKB/Swiss-Prot
    Q86XK3
    Related
    ENSP00000358742.3, ENST00000369727.4
    Conserved Domains (1) summary
    pfam10376
    Location:25236
    Mei5; Double-strand recombination repair protein
  2. NM_001384829.1NP_001371758.1  swi5-dependent recombination DNA repair protein 1 homolog isoform b

    Status: VALIDATED

    Source sequence(s)
    AL357336
    Conserved Domains (1) summary
    pfam10376
    Location:12223
    Mei5; Double-strand recombination repair protein
  3. NM_001384830.1NP_001371759.1  swi5-dependent recombination DNA repair protein 1 homolog isoform b

    Status: VALIDATED

    Source sequence(s)
    AL357336
    Conserved Domains (1) summary
    pfam10376
    Location:12223
    Mei5; Double-strand recombination repair protein
  4. NM_145247.5NP_660290.3  swi5-dependent recombination DNA repair protein 1 homolog isoform b

    See identical proteins and their annotated locations for NP_660290.3

    Status: VALIDATED

    Source sequence(s)
    AL357336
    Consensus CDS
    CCDS31280.1
    UniProtKB/Swiss-Prot
    Q86XK3
    Related
    ENSP00000358744.3, ENST00000369729.7
    Conserved Domains (1) summary
    pfam10376
    Location:12223
    Mei5; Double-strand recombination repair protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    104120166..104126385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269521.3XP_005269578.1  swi5-dependent recombination DNA repair protein 1 homolog isoform X1

    See identical proteins and their annotated locations for XP_005269578.1

    UniProtKB/Swiss-Prot
    Q86XK3
    Conserved Domains (1) summary
    pfam10376
    Location:87298
    Mei5; Double-strand recombination repair protein
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