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Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 [ Mus musculus (house mouse) ]

Gene ID: 11938, updated on 8-Jan-2023

Summary

Official Symbol
Atp2a2provided by MGI
Official Full Name
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2provided by MGI
Primary source
MGI:MGI:88110
See related
Ensembl:ENSMUSG00000029467 AllianceGenome:MGI:88110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SERCA2; SERCA2B; Serca2a; D5Wsu150e; mKIAA4195; 9530097L16Rik
Summary
Enables several functions, including P-type calcium transporter activity; calcium ion binding activity; and protein C-terminus binding activity. Acts upstream of or within several processes, including T-tubule organization; cardiac muscle hypertrophy in response to stress; and regulation of heart contraction. Located in endoplasmic reticulum membrane; ribbon synapse; and sarcoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Used to study keratosis follicularis. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 1140.8), bladder adult (RPKM 124.3) and 3 other tissues See more
Orthologs
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Genomic context

See Atp2a2 in Genome Data Viewer
Location:
5 62.38 cM; 5 F
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122591576..122640288, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122453513..122502225, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32853 Neighboring gene actin related protein 2/3 complex, subunit 3 Neighboring gene anaphase promoting complex subunit 7 Neighboring gene RIKEN cDNA 1700040P09 gene Neighboring gene predicted gene, 22965

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA4195

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables P-type calcium transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables P-type calcium transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables P-type calcium transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential ISO
Inferred from Sequence Orthology
more info
 
enables S100 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables lncRNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lutropin-choriogonadotropic hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within ER-nucleus signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T-tubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagosome membrane docking ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion import into sarcoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion import into sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transport from cytosol to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in endoplasmic reticulum calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrion-endoplasmic reticulum membrane tethering ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of heart contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of receptor binding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron cellular homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in organelle localization by membrane tethering ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within organelle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of endoplasmic reticulum calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endoplasmic reticulum calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of calcium ion-dependent exocytosis of neurotransmitter IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle cell membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle contraction by calcium ion signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cardiac muscle contraction by calcium ion signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of muscle contraction TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of the force of heart contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in relaxation of cardiac muscle ISO
Inferred from Sequence Orthology
more info
 
involved_in response to peptide hormone ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sarcoplasmic reticulum calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sarcoplasmic reticulum calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within transition between fast and slow fiber IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical ectoplasmic specialization ISO
Inferred from Sequence Orthology
more info
 
part_of calcium ion-transporting ATPase complex ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with intercalated disc ISO
Inferred from Sequence Orthology
more info
 
located_in longitudinal sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane bounded cell projection ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in ribbon synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
located_in sarcoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Names
SR Ca(2+)-ATPase 2
calcium pump 2
endoplasmic reticulum class 1/2 Ca(2+) ATPase
sarco/endoplasmic reticulum Ca2+-ATPase 2
NP_001103610.1
NP_033852.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110140.3NP_001103610.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b

    See identical proteins and their annotated locations for NP_001103610.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (b), also known as SERCA2B.
    Source sequence(s)
    AJ131821, AK220538, CF742600, CJ162528
    Consensus CDS
    CCDS57378.1
    UniProtKB/Swiss-Prot
    O55143, Q9WUT5
    UniProtKB/TrEMBL
    A0A8C6H290, Q5DTI2
    Related
    ENSMUSP00000031423.9, ENSMUST00000031423.10
    Conserved Domains (6) summary
    TIGR01116
    Location:53988
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:93340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:783986
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:605711
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419527
    Cation_ATPase; Cation transport ATPase (P-type)
  2. NM_009722.3NP_033852.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a

    See identical proteins and their annotated locations for NP_033852.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (a), also known as SERCA2A, has a shorter and distinct C-terminus compared to isoform b.
    Source sequence(s)
    AK220538, BC054748, CJ162528
    Consensus CDS
    CCDS57379.1
    UniProtKB/Swiss-Prot
    O55143
    UniProtKB/TrEMBL
    A0A8C6H523, Q5DTI2
    Related
    ENSMUSP00000136104.2, ENSMUST00000177974.8
    Conserved Domains (6) summary
    TIGR01116
    Location:53988
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:93340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:783986
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:472
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:605711
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419527
    Cation_ATPase; Cation transport ATPase (P-type)

RNA

  1. NR_027838.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents a longer 3' UTR, compared to variant 1. This variant is represented as non-coding because the additional splicing in the 3' UTR renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK220538, BC054531, CJ162528

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    122591576..122640288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)