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mutL DNA mismatch repair protein MutL [ Aquifex aeolicus VF5 ]

Gene ID: 1193141, discontinued on 6-Mar-2020
  • This record was discontinued.
Gene symbol
mutL
Gene description
DNA mismatch repair protein MutL
Locus tag
aq_1578
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Aquifex aeolicus VF5 (strain: VF5)
Lineage
Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex
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Genomic Sequence:
NC_000918.1

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The overall structure of the ATPase domain of MutL was comprised of 2 subdomains: the N-terminal ATP-binding subdomain and the C-terminal alpha-beta sandwich subdomain. Site-directed mutagenesis experiment identified DNA-interacting 8 basic AAs distributed across both the 2 subdomains and formed a DNA-binding cleft. The 2 separate DNA-binding sites in the full-length A. aeolicus MutL simultaneously bind a dsDNA molecule.
    Title: Crystal structure and DNA-binding property of the ATPase domain of bacterial mismatch repair endonuclease MutL from Aquifex aeolicus.
  2. The N-terminal domain (NTD) of MutL is monomeric and exhibits a relatively strong DNA-binding activity; it is also clear that NTD promotes the endonuclease activity of carboxyl-terminal domain (CTD).
    Title: Characterization of C- and N-terminal domains of Aquifex aeolicus MutL endonuclease: N-terminal domain stimulates the endonuclease activity of C-terminal domain in a zinc-dependent manner.
  3. A. aeolicus MutL is a human PMS2 homologue that stimulates a PcrA/UvrD/Rep subfamily helicase
    Title: A human PMS2 homologue from Aquifex aeolicus stimulates an ATP-dependent DNA helicase.
  4. Adenosine triphosphate stimulates Aquifex aeolicus MutL endonuclease activity
    Title: Adenosine triphosphate stimulates Aquifex aeolicus MutL endonuclease activity.
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Names
DNA mismatch repair protein MutL

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000918.1 Reference assembly

    Range
    1113601..1114878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_214083.1 DNA mismatch repair protein MutL [Aquifex aeolicus VF5]

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O67518.1

Gene LinkOut

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Research Materials