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Atox1 antioxidant 1 copper chaperone [ Mus musculus (house mouse) ]

Gene ID: 11927, updated on 18-Sep-2024

Summary

Official Symbol
Atox1provided by MGI
Official Full Name
antioxidant 1 copper chaperoneprovided by MGI
Primary source
MGI:MGI:1333855
See related
Ensembl:ENSMUSG00000018585 AllianceGenome:MGI:1333855
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atx1
Summary
Predicted to enable several functions, including ATPase binding activity; copper-dependent protein binding activity; and cuprous ion binding activity. Acts upstream of or within cellular copper ion homeostasis and copper ion transport. Predicted to be active in cytosol. Orthologous to human ATOX1 (antioxidant 1 copper chaperone). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 244.6), kidney adult (RPKM 226.0) and 28 other tissues See more
Orthologs
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Genomic context

See Atox1 in Genome Data Viewer
Location:
11 B1.3; 11 33.07 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (55337463..55352034, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (55446637..55461208, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31842 Neighboring gene STARR-seq mESC enhancer starr_29535 Neighboring gene secreted acidic cysteine rich glycoprotein Neighboring gene STARR-seq mESC enhancer starr_29537 Neighboring gene STARR-seq mESC enhancer starr_29542 Neighboring gene STARR-seq mESC enhancer starr_29544 Neighboring gene STARR-positive B cell enhancer ABC_E373 Neighboring gene predicted gene 12235 Neighboring gene G3BP stress granule assembly factor 1 Neighboring gene predicted gene 12238

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables copper chaperone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables copper chaperone activity IEA
Inferred from Electronic Annotation
more info
 
enables copper chaperone activity ISO
Inferred from Sequence Orthology
more info
 
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
 
enables copper-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
enables copper-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables cuprous ion binding IEA
Inferred from Electronic Annotation
more info
 
enables cuprous ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in copper ion export ISO
Inferred from Sequence Orthology
more info
 
involved_in copper ion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within copper ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
copper transport protein ATOX1
Names
ATX1 (antioxidant protein 1) homolog 1
metal transport protein ATX1
NP_033850.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009720.3NP_033850.1  copper transport protein ATOX1

    See identical proteins and their annotated locations for NP_033850.1

    Status: VALIDATED

    Source sequence(s)
    BP773958, BQ747750
    Consensus CDS
    CCDS36158.1
    UniProtKB/Swiss-Prot
    O08997, Q5NCU2
    Related
    ENSMUSP00000104485.2, ENSMUST00000108857.2
    Conserved Domains (1) summary
    cd00371
    Location:563
    HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    55337463..55352034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)