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Neurod6 neurogenic differentiation 6 [ Mus musculus (house mouse) ]

Gene ID: 11922, updated on 31-Jan-2023

Summary

Official Symbol
Neurod6provided by MGI
Official Full Name
neurogenic differentiation 6provided by MGI
Primary source
MGI:MGI:106593
See related
Ensembl:ENSMUSG00000037984 AllianceGenome:MGI:106593
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nex; Atoh2; Math2; Nex1m; Math-2; bHLHa2
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within dentate gyrus development. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; integumental system; limb; nervous system; and sensory organ. Orthologous to human NEUROD6 (neuronal differentiation 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 67.3), CNS E14 (RPKM 57.9) and 3 other tissues See more
Orthologs
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Genomic context

See Neurod6 in Genome Data Viewer
Location:
6 B3; 6 27.53 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (55654803..55658248, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (55677818..55681263, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene adenylate cyclase activating polypeptide 1 receptor 1 Neighboring gene predicted gene, 34441 Neighboring gene phosphoglycerate mutase 1 pseudogene Neighboring gene predicted gene 3279 Neighboring gene predicted gene, 38820

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Homology

Clone Names

  • MGC90713

General protein information

Preferred Names
neurogenic differentiation factor 6
Names
atonal homolog 2
helix-loop-helix protein mATH-2
protein NEX-1
protein atonal homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009717.2NP_033847.1  neurogenic differentiation factor 6

    See identical proteins and their annotated locations for NP_033847.1

    Status: VALIDATED

    Source sequence(s)
    AK144360, AK144377, CJ237964
    Consensus CDS
    CCDS20168.1
    UniProtKB/Swiss-Prot
    P48986
    UniProtKB/TrEMBL
    A0A8C6HNZ2, Q3UN97, Q5M8T7
    Related
    ENSMUSP00000047016.9, ENSMUST00000044767.10
    Conserved Domains (2) summary
    pfam12533
    Location:153272
    Neuro_bHLH; Neuronal helix-loop-helix transcription factor
    cd19722
    Location:82151
    bHLH_TS_NeuroD6_ATOH2; basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 6 (NeuroD6) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    55654803..55658248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)