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Atf1 activating transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 11908, updated on 9-Jan-2022

Summary

Official Symbol
Atf1provided by MGI
Official Full Name
activating transcription factor 1provided by MGI
Primary source
MGI:MGI:1298366
See related
Ensembl:ENSMUSG00000023027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables DNA binding activity. Predicted to be involved in cellular protein-containing complex assembly; positive regulation of macromolecule biosynthetic process; and positive regulation of neuron projection development. Part of ATF1-ATF4 transcription factor complex. Is expressed in several structures, including branchial arch; early conceptus; genitourinary system; limb; and maxillary process. Orthologous to human ATF1 (activating transcription factor 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in testis adult (RPKM 24.0), liver E14 (RPKM 14.5) and 28 other tissues See more
Orthologs
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Genomic context

See Atf1 in Genome Data Viewer
Location:
15; 15 F1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100125740..100159129)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100227859..100261248)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (100058290..100091679)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310068J16 gene Neighboring gene La ribonucleoprotein domain family, member 4 Neighboring gene disco interacting protein 2 homolog B Neighboring gene transmembrane (C-terminal) protease, serine 12 Neighboring gene predicted gene, 33666

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in biomineralization ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in response to inorganic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to inorganic substance ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in response to purine-containing compound ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
part_of ATF1-ATF4 transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ATF1-ATF4 transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
part_of ATF4-CREB1 transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclic AMP-dependent transcription factor ATF-1
Names
TCR-ATF1
cAMP-dependent transcription factor ATF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007497.3NP_031523.3  cyclic AMP-dependent transcription factor ATF-1

    See identical proteins and their annotated locations for NP_031523.3

    Status: VALIDATED

    Source sequence(s)
    AC124479, AK010428, BY733806
    Consensus CDS
    CCDS27832.1
    UniProtKB/Swiss-Prot
    P81269
    UniProtKB/TrEMBL
    Q9CWS2
    Related
    ENSMUSP00000023769.5, ENSMUST00000023769.11
    Conserved Domains (2) summary
    cd14690
    Location:213267
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:4882
    pKID; pKID domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    100125740..100159129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520351.5XP_006520414.1  cyclic AMP-dependent transcription factor ATF-1 isoform X1

    See identical proteins and their annotated locations for XP_006520414.1

    UniProtKB/Swiss-Prot
    P81269
    Conserved Domains (2) summary
    cd14690
    Location:213267
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:4882
    pKID; pKID domain
  2. XM_006520352.5XP_006520415.1  cyclic AMP-dependent transcription factor ATF-1 isoform X1

    See identical proteins and their annotated locations for XP_006520415.1

    UniProtKB/Swiss-Prot
    P81269
    Conserved Domains (2) summary
    cd14690
    Location:213267
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:4882
    pKID; pKID domain
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