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vopS T3SS effector adenosine monophosphate-protein transferase VopS [ Vibrio parahaemolyticus RIMD 2210633 ]

Gene ID: 1189193, updated on 27-Apr-2025
Gene symbol
vopS
Gene description
T3SS effector adenosine monophosphate-protein transferase VopS
Locus tag
VP_RS08115
Gene type
protein coding
Organism
Vibrio parahaemolyticus RIMD 2210633 (strain: RIMD 2210633, substrain: RIMD 2210633)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio
Old locus tag
VP1686
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Location:
chromosome: 1
Sequence:
Chromosome: 1; NC_004603.1 (1799324..1800487, complement)

Chromosome 1 - NC_004603.1Genomic Context describing neighboring genes Neighboring gene type III secretion system effector VopR Neighboring gene type III secretion system chaperone Neighboring gene CesT family type III secretion system chaperone Neighboring gene SctL family type III secretion system stator protein VscL Neighboring gene SctK family type III secretion system sorting platform protein VscK

Genomic Sequence:
NC_004603.1

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The VopS effector (VP1686) fic domain AMPylates Rho-family GTPases to disrupt effector binding and downstream signaling.
    Title: AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling.
  2. We report that Vibrio parahaemolyticus induces a rapid remodeling of macrophage actin and activates RhoB GTPase via type III secretion system 1 regulated translocation of the effector protein, VP1686, into the macrophages.
    Title: Translocation of VP1686 upregulates RhoB and accelerates phagocytic activity of macrophage through actin remodeling.
  3. Required for Rho-family GTPase inhibition
    Title: Vibrio parahaemolyticus inhibition of Rho family GTPase activation requires a functional chromosome I type III secretion system.
  4. appears to be one of 3 TTSS effector proteins in V. parahaemolyticus
    Title: Identification of proteins secreted via Vibrio parahaemolyticus type III secretion system 1.
  5. Vibrio effector protein VP1686 activates a conserved apoptotic pathway in macrophages through suppression of NF-kappaB activation independent of Toll-like receptor signaling
    Title: VP1686, a Vibrio type III secretion protein, induces toll-like receptor-independent apoptosis in macrophage through NF-kappaB inhibition.
Submit: New GeneRIF Correction
Preferred Names
T3SS effector adenosine monophosphate-protein transferase VopS

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004603.1 Reference assembly

    Range
    1799324..1800487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_005464511.1 T3SS effector adenosine monophosphate-protein transferase VopS [Vibrio parahaemolyticus]

    See identical proteins and their annotated locations for WP_005464511.1

    UniProtKB/Swiss-Prot
    Q87P32
    UniProtKB/TrEMBL
    A0A6H0JHV2, A0AAW3IPL3
    Conserved Domains (1) summary
    PRK14052
    Location:1 → 387
    PRK14052; adenosine monophosphate-protein transferase vopS
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q87P32.1

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