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ZNF488 zinc finger protein 488 [ Homo sapiens (human) ]

Gene ID: 118738, updated on 12-Oct-2019

Summary

Official Symbol
ZNF488provided by HGNC
Official Full Name
zinc finger protein 488provided by HGNC
Primary source
HGNC:HGNC:23535
See related
Ensembl:ENSG00000265763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in duodenum (RPKM 8.5), brain (RPKM 5.3) and 4 other tissues See more
Orthologs

Genomic context

See ZNF488 in Genome Data Viewer
Location:
10q11.22
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (47365482..47384339, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (48355029..48373866)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene growth differentiation factor 2 Neighboring gene uncharacterized LOC107001062 Neighboring gene uncharacterized LOC105378292 Neighboring gene retinol binding protein 3 Neighboring gene annexin A8 Neighboring gene family with sequence similarity 25 member G

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32104

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
oligodendrocyte development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of myelination IEA
Inferred from Electronic Annotation
more info
 
positive regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346932.2NP_001333861.1  zinc finger protein 488

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest transcript. All six variants encode the same protein.
    Source sequence(s)
    AL731561
    Consensus CDS
    CCDS73120.1
    UniProtKB/Swiss-Prot
    Q96MN9
    Conserved Domains (1) summary
    sd00017
    Location:277297
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001346933.2NP_001333862.1  zinc finger protein 488

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AL731561
    Consensus CDS
    CCDS73120.1
    UniProtKB/Swiss-Prot
    Q96MN9
    Conserved Domains (1) summary
    sd00017
    Location:277297
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001346934.2NP_001333863.1  zinc finger protein 488

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AL731561
    Consensus CDS
    CCDS73120.1
    UniProtKB/Swiss-Prot
    Q96MN9
    Conserved Domains (1) summary
    sd00017
    Location:277297
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001346935.2NP_001333864.1  zinc finger protein 488

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AL731561
    Consensus CDS
    CCDS73120.1
    UniProtKB/Swiss-Prot
    Q96MN9
    Conserved Domains (1) summary
    sd00017
    Location:277297
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001346936.2NP_001333865.1  zinc finger protein 488

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AL731561
    Consensus CDS
    CCDS73120.1
    UniProtKB/Swiss-Prot
    Q96MN9
    Conserved Domains (1) summary
    sd00017
    Location:277297
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_153034.4NP_694579.1  zinc finger protein 488

    See identical proteins and their annotated locations for NP_694579.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All six variants encode the same protein.
    Source sequence(s)
    AL731561, BC051323
    Consensus CDS
    CCDS73120.1
    UniProtKB/Swiss-Prot
    Q96MN9
    Related
    ENSP00000462269.1, ENST00000585316.3
    Conserved Domains (1) summary
    sd00017
    Location:277297
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    47365482..47384339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717617.3XP_006717680.1  zinc finger protein 488 isoform X1

    See identical proteins and their annotated locations for XP_006717680.1

    UniProtKB/Swiss-Prot
    Q96MN9
    Conserved Domains (1) summary
    sd00017
    Location:277297
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_011539244.2XP_011537546.1  zinc finger protein 488 isoform X1

    See identical proteins and their annotated locations for XP_011537546.1

    UniProtKB/Swiss-Prot
    Q96MN9
    Conserved Domains (1) summary
    sd00017
    Location:277297
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_017015643.1XP_016871132.1  zinc finger protein 488 isoform X1

    UniProtKB/Swiss-Prot
    Q96MN9
    Conserved Domains (1) summary
    sd00017
    Location:277297
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_024447789.1XP_024303557.1  zinc finger protein 488 isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:277297
    ZF_C2H2; C2H2 Zn finger [structural motif]
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