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Art2b ADP-ribosyltransferase 2b [ Mus musculus (house mouse) ]

Gene ID: 11872, updated on 13-Oct-2022

Summary

Official Symbol
Art2bprovided by MGI
Official Full Name
ADP-ribosyltransferase 2bprovided by MGI
Primary source
MGI:MGI:107545
See related
Ensembl:ENSMUSG00000030651 AllianceGenome:MGI:107545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Art; Rt6; Rt-6; ARTC2; Ly92b; Rt6-2; ART2.2
Summary
Enables NAD(P)+-protein-arginine ADP-ribosyltransferase activity and hydrolase activity, acting on glycosyl bonds. Involved in NAD catabolic process. Acts upstream of or within peptidyl-arginine ADP-ribosylation. Is anchored component of external side of plasma membrane. Orthologous to human ART2BP (ADP-ribosyltransferase 2B, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 3.9), mammary gland adult (RPKM 1.9) and 6 other tissues See more
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Genomic context

See Art2b in Genome Data Viewer
Location:
7 E2; 7 54.61 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101224936..101234790, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101575729..101585591, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19765 Neighboring gene ADP-ribosyltransferase 2a Neighboring gene ribosomal protein L6 pseudogene Neighboring gene predicted gene, 45995 Neighboring gene ClpB caseinolytic peptidase B Neighboring gene paired-like homeobox 2a Neighboring gene inositol polyphosphate phosphatase-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD glycohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD+-protein-arginine ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD+-protein-arginine ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in NAD catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extrinsic component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
T-cell ecto-ADP-ribosyltransferase 2
Names
ADP-ribosyltransferase C2 and C3 toxin-like 2
NAD(+) glycohydrolase
T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 2
T-cell differentiation marker Rt6 homolog 2
T-cell mono(ADP-ribosyl)transferase 2
mono(ADP-ribosyl)transferase 2B
NP_064299.2
XP_006507319.1
XP_017177440.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019915.3NP_064299.2  T-cell ecto-ADP-ribosyltransferase 2 precursor

    See identical proteins and their annotated locations for NP_064299.2

    Status: VALIDATED

    Source sequence(s)
    AC129609, AF016465
    Consensus CDS
    CCDS21512.1
    UniProtKB/Swiss-Prot
    O35702, O35975
    Related
    ENSMUSP00000065658.3, ENSMUST00000063920.3
    Conserved Domains (1) summary
    pfam01129
    Location:27242
    ART; NAD:arginine ADP-ribosyltransferase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101224936..101234790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507256.4XP_006507319.1  T-cell ecto-ADP-ribosyltransferase 2 isoform X2

    See identical proteins and their annotated locations for XP_006507319.1

    UniProtKB/Swiss-Prot
    O35702, O35975
    Related
    ENSMUSP00000147267.2, ENSMUST00000209526.2
    Conserved Domains (1) summary
    pfam01129
    Location:27242
    ART; NAD:arginine ADP-ribosyltransferase
  2. XM_017321951.2XP_017177440.1  T-cell ecto-ADP-ribosyltransferase 2 isoform X1

    Conserved Domains (1) summary
    pfam01129
    Location:38253
    ART; NAD:arginine ADP-ribosyltransferase