PSTK phosphoseryl-tRNA kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: PSTKprovided by HGNC
Official Full Name: phosphoseryl-tRNA kinaseprovided by HGNC
Primary source: HGNC:HGNC:28578
See related: Ensembl:ENSG00000179988 MIM:611310; AllianceGenome:HGNC:28578
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C10orf89
Summary: Predicted to enable kinase activity and tRNA binding activity. Predicted to be involved in translation. Predicted to act upstream of or within selenocysteine incorporation. [provided by Alliance of Genome Resources, Jun 2025]
Expression: Ubiquitous expression in bone marrow (RPKM 1.8), testis (RPKM 1.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q26.13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (122980401..122990390)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (123855384..123865385)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (124739917..124749906)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Same but different - Molecular comparison of human KTI12 and PSTK.
Title: Same but different - Molecular comparison of human KTI12 and PSTK.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables L-seryl-tRNA(Sec) kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in translation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: L-seryl-tRNA(Sec) kinase

Names: O-phosphoseryl-tRNA(Sec) kinase

NP_001350460.1

EC 2.7.1.164

NP_699167.2

EC 2.7.1.164

XP_016871130.1

EC 2.7.1.164

XP_054220687.1

EC 2.7.1.164

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363531.2 → NP_001350460.1 L-seryl-tRNA(Sec) kinase isoform 1

Status: VALIDATED

Source sequence(s)

AC073585

Consensus CDS

CCDS86153.1

UniProtKB/TrEMBL

H7BYY4

Related

ENSP00000384653.3, ENST00000406217.8

Conserved Domains (1) summary

TIGR03575
Location:20 → 357

selen_PSTK_euk; L-seryl-tRNA(Sec) kinase, eukaryotic
NM_153336.3 → NP_699167.2 L-seryl-tRNA(Sec) kinase isoform 2

See identical proteins and their annotated locations for NP_699167.2

Status: VALIDATED

Source sequence(s)

AC073585, BC035344

Consensus CDS

CCDS7633.1

UniProtKB/Swiss-Prot

Q6ZSS9, Q8IV42

Related

ENSP00000357882.3, ENST00000368887.7

Conserved Domains (2) summary

pfam13671
Location:20 → 212

AAA_33; AAA domain

cl17190
Location:20 → 301

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...