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PSTK phosphoseryl-tRNA kinase [ Homo sapiens (human) ]

Gene ID: 118672, updated on 9-Jun-2025
Official Symbol
PSTKprovided by HGNC
Official Full Name
phosphoseryl-tRNA kinaseprovided by HGNC
Primary source
HGNC:HGNC:28578
See related
Ensembl:ENSG00000179988 MIM:611310; AllianceGenome:HGNC:28578
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C10orf89
Summary
Predicted to enable kinase activity and tRNA binding activity. Predicted to be involved in translation. Predicted to act upstream of or within selenocysteine incorporation. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Ubiquitous expression in bone marrow (RPKM 1.8), testis (RPKM 1.5) and 25 other tissues See more
Orthologs
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See PSTK in Genome Data Viewer
Location:
10q26.13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (122980401..122990390)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (123855384..123865385)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (124739917..124749906)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene chromosome 10 open reading frame 88 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2894 Neighboring gene uncharacterized LOC124902519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4143 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:124760713-124760899 Neighboring gene IKAROS family zinc finger 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4145 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:124776916-124777782 Neighboring gene acyl-CoA dehydrogenase short/branched chain Neighboring gene Sharpr-MPRA regulatory region 2783 Neighboring gene Sharpr-MPRA regulatory region 13327

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC35392

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables L-seryl-tRNA(Sec) kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
L-seryl-tRNA(Sec) kinase
Names
O-phosphoseryl-tRNA(Sec) kinase
NP_001350460.1
NP_699167.2
XP_016871130.1
XP_054220687.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363531.2NP_001350460.1  L-seryl-tRNA(Sec) kinase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC073585
    Consensus CDS
    CCDS86153.1
    UniProtKB/TrEMBL
    H7BYY4
    Related
    ENSP00000384653.3, ENST00000406217.8
    Conserved Domains (1) summary
    TIGR03575
    Location:20357
    selen_PSTK_euk; L-seryl-tRNA(Sec) kinase, eukaryotic
  2. NM_153336.3NP_699167.2  L-seryl-tRNA(Sec) kinase isoform 2

    See identical proteins and their annotated locations for NP_699167.2

    Status: VALIDATED

    Source sequence(s)
    AC073585, BC035344
    Consensus CDS
    CCDS7633.1
    UniProtKB/Swiss-Prot
    Q6ZSS9, Q8IV42
    Related
    ENSP00000357882.3, ENST00000368887.7
    Conserved Domains (2) summary
    pfam13671
    Location:20212
    AAA_33; AAA domain
    cl17190
    Location:20301
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    122980401..122990390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015641.3XP_016871130.1  L-seryl-tRNA(Sec) kinase isoform X1

RNA

  1. XR_001747018.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    123855384..123865385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364712.1XP_054220687.1  L-seryl-tRNA(Sec) kinase isoform X1

RNA

  1. XR_008488161.1 RNA Sequence