U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Arpc1b actin related protein 2/3 complex, subunit 1B [ Mus musculus (house mouse) ]

Gene ID: 11867, updated on 5-Feb-2023

Summary

Official Symbol
Arpc1bprovided by MGI
Official Full Name
actin related protein 2/3 complex, subunit 1Bprovided by MGI
Primary source
MGI:MGI:1343142
See related
Ensembl:ENSMUSG00000029622 AllianceGenome:MGI:1343142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L72; 41kDa; SOP2Hs; p41-ARC
Summary
Predicted to enable actin filament binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in actin cytoskeleton; cytoplasm; and nucleus. Predicted to be part of Arp2/3 protein complex and tubulobulbar complex. Is expressed in central nervous system; early conceptus; genitourinary system; and retina. Human ortholog(s) of this gene implicated in gastritis; immunodeficiency 71; and myelodysplastic syndrome. Orthologous to human ARPC1B (actin related protein 2/3 complex subunit 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 219.0), ovary adult (RPKM 201.5) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Arpc1b in Genome Data Viewer
Location:
5; 5 G2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145051066..145064996)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145114256..145128186)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700018F24 gene Neighboring gene actin related protein 2/3 complex, subunit 1A Neighboring gene PDGFA associated protein 1 Neighboring gene BUD31 homolog Neighboring gene pentatricopeptide repeat domain 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102425

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Arp2/3 protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Arp2/3 protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of Arp2/3 protein complex TAS
Traceable Author Statement
more info
PubMed 
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of tubulobulbar complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
actin-related protein 2/3 complex subunit 1B
Names
arp2/3 complex 41 kDa subunit

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023142.2NP_075631.2  actin-related protein 2/3 complex subunit 1B

    See identical proteins and their annotated locations for NP_075631.2

    Status: VALIDATED

    Source sequence(s)
    AK153510, AK159371, BF660612
    Consensus CDS
    CCDS19856.1
    UniProtKB/Swiss-Prot
    Q9CRC4, Q9WV32
    Related
    ENSMUSP00000082822.7, ENSMUST00000085679.13
    Conserved Domains (2) summary
    sd00039
    Location:1150
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:45264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    145051066..145064996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)