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Arnt aryl hydrocarbon receptor nuclear translocator [ Mus musculus (house mouse) ]

Gene ID: 11863, updated on 2-Nov-2024

Summary

Official Symbol
Arntprovided by MGI
Official Full Name
aryl hydrocarbon receptor nuclear translocatorprovided by MGI
Primary source
MGI:MGI:88071
See related
Ensembl:ENSMUSG00000015522 AllianceGenome:MGI:88071
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Drnt; Hif1b; ESTM42; bHLHe2; mKIAA4051; D3Ertd557e
Summary
Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Contributes to nuclear receptor activity. Involved in positive regulation of protein sumoylation. Acts upstream of or within several processes, including embryonic placenta development; positive regulation of transcription by RNA polymerase II; and response to hypoxia. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human ARNT (aryl hydrocarbon receptor nuclear translocator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 15.4), ovary adult (RPKM 15.3) and 28 other tissues See more
Orthologs
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Genomic context

See Arnt in Genome Data Viewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95341674..95404551)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95434367..95497240)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08383 Neighboring gene 28S ribosomal protein S16, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E654 Neighboring gene SET domain, bifurcated 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08385 Neighboring gene cathepsin K Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95315769-95315952 Neighboring gene predicted gene, 40096

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4051

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables aryl hydrocarbon receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables aryl hydrocarbon receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
contributes_to nuclear receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to nuclear receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of vascular endothelial growth factor production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to toxic substance TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of aryl hydrocarbon receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of nuclear aryl hydrocarbon receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear aryl hydrocarbon receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
aryl hydrocarbon receptor nuclear translocator
Names
HIF-1-beta
HIF1-beta
dioxin receptor, nuclear translocator
hypoxia-inducible factor 1-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037737.2NP_001032826.1  aryl hydrocarbon receptor nuclear translocator isoform a

    See identical proteins and their annotated locations for NP_001032826.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC092203, AK145415, AK153355, CJ183661
    Consensus CDS
    CCDS17614.1
    UniProtKB/Swiss-Prot
    P53762, Q60661, Q921F3
    UniProtKB/TrEMBL
    Q3U7X2
    Related
    ENSMUSP00000099810.5, ENSMUST00000102749.11
    Conserved Domains (5) summary
    smart00091
    Location:166230
    PAS; PAS domain
    cd00130
    Location:362458
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:91143
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:163269
    PAS; PAS fold
    pfam14598
    Location:362462
    PAS_11; PAS domain
  2. NM_001409517.1NP_001396446.1  aryl hydrocarbon receptor nuclear translocator isoform c

    Status: VALIDATED

    Source sequence(s)
    AC092202, AC092203
  3. NM_001409518.1NP_001396447.1  aryl hydrocarbon receptor nuclear translocator isoform d

    Status: VALIDATED

    Source sequence(s)
    AC092202, AC092203
  4. NM_001409519.1NP_001396448.1  aryl hydrocarbon receptor nuclear translocator isoform e

    Status: VALIDATED

    Source sequence(s)
    AC092202, AC092203
  5. NM_001409520.1NP_001396449.1  aryl hydrocarbon receptor nuclear translocator isoform f

    Status: VALIDATED

    Source sequence(s)
    AC092202, AC092203
    UniProtKB/TrEMBL
    Q8CEC2
    Related
    ENSMUSP00000102779.2, ENSMUST00000107161.8
  6. NM_001409522.1NP_001396451.1  aryl hydrocarbon receptor nuclear translocator isoform g

    Status: VALIDATED

    Source sequence(s)
    AC092202, AC092203
  7. NM_009709.4NP_033839.2  aryl hydrocarbon receptor nuclear translocator isoform b

    See identical proteins and their annotated locations for NP_033839.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal coding exon, as compared to variant 1. The encoded isoform b lacks an internal segment, as compared to isoform a.
    Source sequence(s)
    AC092203, AK145415, CJ183661
    Consensus CDS
    CCDS38546.1
    UniProtKB/TrEMBL
    Q3U7X2, Q3ULM2
    Related
    ENSMUSP00000088313.6, ENSMUST00000090804.12
    Conserved Domains (5) summary
    smart00091
    Location:151215
    PAS; PAS domain
    cd00130
    Location:347443
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:76128
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:148254
    PAS; PAS fold
    pfam14598
    Location:347447
    PAS_11; PAS domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95341674..95404551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500933.4XP_006500996.1  aryl hydrocarbon receptor nuclear translocator isoform X5

    Conserved Domains (3) summary
    smart00091
    Location:362415
    PAS; PAS domain
    pfam00989
    Location:163269
    PAS; PAS fold
    cd18947
    Location:86150
    bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
  2. XM_030252391.1XP_030108251.1  aryl hydrocarbon receptor nuclear translocator isoform X3

    UniProtKB/TrEMBL
    Q5DTR2
    Conserved Domains (3) summary
    pfam00989
    Location:97203
    PAS; PAS fold
    pfam14598
    Location:296396
    PAS_11; PAS domain
    cd18947
    Location:2084
    bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
  3. XM_030252392.1XP_030108252.1  aryl hydrocarbon receptor nuclear translocator isoform X4

    UniProtKB/TrEMBL
    Q5DTR2
    Conserved Domains (3) summary
    pfam00989
    Location:59165
    PAS; PAS fold
    pfam14598
    Location:258358
    PAS_11; PAS domain
    cl00081
    Location:146
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  4. XM_030252393.1XP_030108253.1  aryl hydrocarbon receptor nuclear translocator isoform X6

    UniProtKB/TrEMBL
    Q3U7X2
    Conserved Domains (4) summary
    pfam00989
    Location:161267
    PAS; PAS fold
    pfam10428
    Location:562703
    SOG2; RAM signalling pathway protein
    pfam14598
    Location:360460
    PAS_11; PAS domain
    cd18947
    Location:84148
    bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins

RNA

  1. XR_001783643.3 RNA Sequence

  2. XR_001783644.3 RNA Sequence