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C10orf90 chromosome 10 open reading frame 90 [ Homo sapiens (human) ]

Gene ID: 118611, updated on 8-Aug-2021

Summary

Official Symbol
C10orf90provided by HGNC
Official Full Name
chromosome 10 open reading frame 90provided by HGNC
Primary source
HGNC:HGNC:26563
See related
Ensembl:ENSG00000154493 MIM:617735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FATS; bA422P15.2
Expression
Biased expression in testis (RPKM 1.4), brain (RPKM 1.2) and 2 other tissues See more
Orthologs
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Genomic context

See C10orf90 in Genome Data Viewer
Location:
10q26.2
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (126424997..126670693, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (128113566..128359262, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 12 Neighboring gene secretion associated Ras related GTPase 1A pseudogene 2 Neighboring gene uncharacterized LOC112267914 Neighboring gene long intergenic non-protein coding RNA 601 Neighboring gene uncharacterized LOC728158 Neighboring gene uncharacterized LOC105378549 Neighboring gene uncharacterized LOC105378548 Neighboring gene uncharacterized LOC105378550 Neighboring gene uncharacterized LOC107984059 Neighboring gene dedicator of cytokinesis 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32938

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
(E2-independent) E3 ubiquitin-conjugating enzyme FATS
Names
E2/E3 hybrid ubiquitin-protein ligase FATS
centrosomal protein C10orf90
fragile-site associated tumor suppressor homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004298.4NP_001004298.2  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 2

    See identical proteins and their annotated locations for NP_001004298.2

    Status: VALIDATED

    Source sequence(s)
    AF435960, AK297577, AL705062, BC034828, CA423069, DB076049
    Consensus CDS
    CCDS31310.1
    UniProtKB/Swiss-Prot
    Q96M02
    Related
    ENSP00000284694.7, ENST00000284694.11
    Conserved Domains (1) summary
    pfam15309
    Location:568697
    ALMS_motif; ALMS motif
  2. NM_001350921.2NP_001337850.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL392108, AL583860, AL589787
    Related
    ENSP00000474558.3, ENST00000488181.3
    Conserved Domains (1) summary
    pfam15309
    Location:665794
    ALMS_motif; ALMS motif
  3. NM_001350922.2NP_001337851.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL392108, AL583860, AL589787
    Conserved Domains (1) summary
    pfam15309
    Location:568697
    ALMS_motif; ALMS motif
  4. NM_001350923.2NP_001337852.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL392108, AL583860, AL589787

RNA

  1. NR_146939.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL392108, AL583860, AL589787

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    126424997..126670693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539217.2XP_011537519.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X1

    Conserved Domains (2) summary
    pfam15309
    Location:596723
    ALMS_motif; ALMS motif
    pfam17730
    Location:79590
    Centro_C10orf90; Centrosomal C10orf90
  2. XM_011539223.2XP_011537525.1  (E2-independent) E3 ubiquitin-conjugating enzyme FATS isoform X2

    See identical proteins and their annotated locations for XP_011537525.1

    Related
    ENSP00000349318.3, ENST00000356858.7
    Conserved Domains (2) summary
    pfam15309
    Location:522649
    ALMS_motif; ALMS motif
    pfam17730
    Location:5516
    Centro_C10orf90; Centrosomal C10orf90

RNA

  1. XR_002956950.1 RNA Sequence

  2. XR_002956946.1 RNA Sequence

  3. XR_002956955.1 RNA Sequence

  4. XR_002956947.1 RNA Sequence

  5. XR_002956951.1 RNA Sequence

  6. XR_002956954.1 RNA Sequence

  7. XR_002956953.1 RNA Sequence

  8. XR_002956949.1 RNA Sequence

  9. XR_002956952.1 RNA Sequence

  10. XR_002956948.1 RNA Sequence

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