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CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1 [ Homo sapiens (human) ]

Gene ID: 118487, updated on 17-Jun-2019

Summary

Official Symbol
CHCHD1provided by HGNC
Official Full Name
coiled-coil-helix-coiled-coil-helix domain containing 1provided by HGNC
Primary source
HGNC:HGNC:23518
See related
Ensembl:ENSG00000172586 MIM:608842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C2360; MRP-S37; C10orf34
Expression
Ubiquitous expression in adrenal (RPKM 18.9), colon (RPKM 18.8) and 25 other tissues See more
Orthologs

Genomic context

See CHCHD1 in Genome Data Viewer
Location:
10q22.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (73782048..73783652)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75541808..75543406)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 11 Neighboring gene uncharacterized LOC107984243 Neighboring gene zinc finger SWIM-type containing 8 Neighboring gene ZSWIM8 antisense RNA 1 Neighboring gene N-deacetylase and N-sulfotransferase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev is identified to have a physical interaction with coiled-coil-helix-coiled-coil-helix domain containing 1 (CHCHD1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Mitochondrial translation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
  • Mitochondrial translation elongation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation elongation, organism-specific biosystemTranslation elongation proceeds by cycles of aminoacyl-tRNAs binding, peptide bond formation, and displacement of deacylated tRNAs (reviewed in Christian and Spremulli 2012). In each cycle an aminoac...
  • Mitochondrial translation initiation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation initiation, organism-specific biosystemTranslation initiates with the mitochondrial mRNA binding the 28S subunit:MTIF3 (28S subunit:IF-3Mt, 28S subunit:IF3mt) complex together with MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP) (reviewed in Christian ...
  • Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
    Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25854

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
fibrillar center IDA
Inferred from Direct Assay
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial ribosome IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
coiled-coil-helix-coiled-coil-helix domain-containing protein 1
Names
28S ribosomal protein S37, mitochondrial
mitochondrial small ribosomal subunit protein mS37
nuclear protein C2360

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203298.3NP_976043.1  coiled-coil-helix-coiled-coil-helix domain-containing protein 1

    See identical proteins and their annotated locations for NP_976043.1

    Status: VALIDATED

    Source sequence(s)
    AC022400, BC020852, BM787401
    Consensus CDS
    CCDS7334.1
    UniProtKB/Swiss-Prot
    Q96BP2
    Related
    ENSP00000361923.5, ENST00000372833.6
    Conserved Domains (1) summary
    pfam06747
    Location:4579
    CHCH; CHCH domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    73782048..73783652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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