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EXOSC6 exosome component 6 [ Homo sapiens (human) ]

Gene ID: 118460, updated on 26-Nov-2021

Summary

Official Symbol
EXOSC6provided by HGNC
Official Full Name
exosome component 6provided by HGNC
Primary source
HGNC:HGNC:19055
See related
Ensembl:ENSG00000223496 MIM:606490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p11; EAP4; MTR3; Mtr3p; hMtr3p
Summary
This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See EXOSC6 in Genome Data Viewer
Location:
16q22.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (70246778..70251940, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70280681..70285843, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371328 Neighboring gene SMG1 pseudogene 7 Neighboring gene alanyl-tRNA synthetase 1 Neighboring gene RNA, 7SL, cytoplasmic 279, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7868 Neighboring gene DEAD-box helicase 19B

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
NOT enables exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA deamination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in RNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in RNA processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in isotype switching ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nuclear mRNA surveillance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in polyadenylation-dependent snoRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of isotype switching IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of exosome (RNase complex) IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
exosome complex component MTR3
Names
Mtr3 (mRNA transport regulator 3)-homolog
exosome complex exonuclease MTR3
hMtr3
homolog of yeast mRNA transport regulator 3
mRNA transport regulator 3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_058219.3NP_478126.1  exosome complex component MTR3

    See identical proteins and their annotated locations for NP_478126.1

    Status: REVIEWED

    Source sequence(s)
    AC009060, BC052252, CX866575
    Consensus CDS
    CCDS10887.1
    UniProtKB/Swiss-Prot
    Q5RKV6
    Related
    ENSP00000398597.1, ENST00000435634.3
    Conserved Domains (1) summary
    cd11371
    Location:36260
    RNase_PH_MTR3; MTR3 subunit of eukaryotic exosome

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    70246778..70251940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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