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Synpo2 synaptopodin 2 [ Mus musculus (house mouse) ]

Gene ID: 118449, updated on 23-May-2018

Summary

Official Symbol
Synpo2provided by MGI
Official Full Name
synaptopodin 2provided by MGI
Primary source
MGI:MGI:2153070
See related
Ensembl:ENSMUSG00000050315 Vega:OTTMUSG00000021275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Myo; AI848603; 1110069I04Rik; 2310068J10Rik; 9530006G20Rik
Expression
Biased expression in bladder adult (RPKM 58.2), subcutaneous fat pad adult (RPKM 12.4) and 8 other tissues See more
Orthologs

Genomic context

See Synpo2 in Genome Data Viewer
Location:
3; 3 G1
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (123076519..123236169, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (122779437..122939067, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 53 Neighboring gene myozenin 2 Neighboring gene Sec24 related gene family, member D (S. cerevisiae) Neighboring gene predicted gene, 40142 Neighboring gene methyltransferase like 14

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC189849

Gene Ontology Provided by MGI

Function Evidence Code Pubs
14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin binding ISA
Inferred from Sequence Alignment
more info
PubMed 
alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
 
filamin binding ISO
Inferred from Sequence Orthology
more info
 
muscle alpha-actinin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
regulation of Rho-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Z disc IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Z disc ISA
Inferred from Sequence Alignment
more info
PubMed 
Z disc ISO
Inferred from Sequence Orthology
more info
 
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress fiber ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with tethering complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
synaptopodin-2
Names
myopodin
mypodin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080451.2NP_536699.2  synaptopodin-2

    Status: VALIDATED

    Source sequence(s)
    AC121315, AC121540
    Consensus CDS
    CCDS51063.1
    UniProtKB/TrEMBL
    E9Q1U2
    Related
    ENSMUSP00000102034.1, OTTMUSP00000023537, ENSMUST00000106426.7, OTTMUST00000050440
    Conserved Domains (1) summary
    cd00992
    Location:785
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    123076519..123236169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500925.2XP_006500988.1  synaptopodin-2 isoform X1

    Related
    ENSMUSP00000142508.1, OTTMUSP00000023534, ENSMUST00000198584.1, OTTMUST00000050436
    Conserved Domains (1) summary
    cd00992
    Location:785
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
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