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Arf2 ADP-ribosylation factor 2 [ Mus musculus (house mouse) ]

Gene ID: 11841, updated on 26-Sep-2022

Summary

Official Symbol
Arf2provided by MGI
Official Full Name
ADP-ribosylation factor 2provided by MGI
Primary source
MGI:MGI:99595
See related
Ensembl:ENSMUSG00000062421 AllianceGenome:MGI:99595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable GTP binding activity and protein domain specific binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to act upstream of or within protein transport. Located in Golgi apparatus. Is expressed in several structures, including central nervous system; cranium; endocrine gland; nasal septum; and reproductive system. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to several human genes including ARF1 (ADP ribosylation factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 36.6), CNS E14 (RPKM 29.3) and 22 other tissues See more
Orthologs
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Genomic context

See Arf2 in Genome Data Viewer
Location:
11 E1; 11 67.64 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (103857551..103876176)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103966725..103985350)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene N-ethylmaleimide sensitive fusion protein Neighboring gene predicted gene, 35365 Neighboring gene CDGSH iron-sulfur domain-containing protein 1 pseudogene Neighboring gene predicted gene, 35420 Neighboring gene predicted gene, 51921 Neighboring gene predicted gene, 42092

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP binding TAS
Traceable Author Statement
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein transport TAS
Traceable Author Statement
more info
PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304574.1NP_001291503.1  ADP-ribosylation factor 2

    See identical proteins and their annotated locations for NP_001291503.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK042977, BY129623, BY683617
    Consensus CDS
    CCDS25525.1
    UniProtKB/Swiss-Prot
    Q8BSL7, Q91VR9
    UniProtKB/TrEMBL
    A0A6P5QN29
    Related
    ENSMUSP00000051814.4, ENSMUST00000057921.10
    Conserved Domains (1) summary
    cl40481
    Location:1180
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases
  2. NM_007477.5NP_031503.1  ADP-ribosylation factor 2

    See identical proteins and their annotated locations for NP_031503.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK053123, BY683617
    Consensus CDS
    CCDS25525.1
    UniProtKB/Swiss-Prot
    Q8BSL7, Q91VR9
    UniProtKB/TrEMBL
    A0A6P5QN29
    Related
    ENSMUSP00000102622.3, ENSMUST00000063347.12
    Conserved Domains (1) summary
    cl40481
    Location:1180
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    103857551..103876176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)