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Arf1 ADP-ribosylation factor 1 [ Mus musculus (house mouse) ]

Gene ID: 11840, updated on 5-Jan-2023

Summary

Official Symbol
Arf1provided by MGI
Official Full Name
ADP-ribosylation factor 1provided by MGI
Primary source
MGI:MGI:99431
See related
Ensembl:ENSMUSG00000048076 AllianceGenome:MGI:99431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables GTP binding activity and magnesium ion binding activity. Involved in mitotic cleavage furrow ingression. Acts upstream of or within vesicle-mediated transport. Located in Golgi apparatus; cytosol; and sarcomere. Part of protein-containing complex. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; integumental system; and nervous system. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARF1 (ADP ribosylation factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 273.0), duodenum adult (RPKM 269.9) and 28 other tissues See more
Orthologs
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Genomic context

See Arf1 in Genome Data Viewer
Location:
11; 11 B1.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (59102238..59119093, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (59211412..59228267, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310033P09 gene Neighboring gene mitochondrial ribosomal protein L55 Neighboring gene wingless-type MMTV integration site family, member 3A Neighboring gene wingless-type MMTV integration site family, member 9A Neighboring gene predicted gene, 51865

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding TAS
Traceable Author Statement
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase D activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Golgi to transport vesicle transport ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in dendritic spine organization ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular copper ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
 
involved_in lysosomal membrane organization ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cleavage furrow ingression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of ER to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of late endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle budding ISO
Inferred from Sequence Orthology
more info
 
involved_in very-low-density lipoprotein particle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within vesicle-mediated transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with COPI-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endomembrane system IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in sarcomere IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ADP-ribosylation factor 1
NP_001123880.1
NP_031502.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130408.2NP_001123880.1  ADP-ribosylation factor 1

    See identical proteins and their annotated locations for NP_001123880.1

    Status: VALIDATED

    Source sequence(s)
    AL645854
    Consensus CDS
    CCDS24765.1
    UniProtKB/Swiss-Prot
    P84078, Q3UF76
    UniProtKB/TrEMBL
    A0A6P5QDI4, A0A8C6HPE6
    Related
    ENSMUSP00000126120.2, ENSMUST00000163300.8
    Conserved Domains (1) summary
    smart00177
    Location:5179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor
  2. NM_007476.4NP_031502.1  ADP-ribosylation factor 1

    See identical proteins and their annotated locations for NP_031502.1

    Status: VALIDATED

    Source sequence(s)
    AL645854
    Consensus CDS
    CCDS24765.1
    UniProtKB/Swiss-Prot
    P84078, Q3UF76
    UniProtKB/TrEMBL
    A0A6P5QDI4, A0A8C6HPE6
    Related
    ENSMUSP00000079905.7, ENSMUST00000061242.8
    Conserved Domains (1) summary
    smart00177
    Location:5179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    59102238..59119093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)