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Arc activity regulated cytoskeletal-associated protein [ Mus musculus (house mouse) ]

Gene ID: 11838, updated on 7-Oct-2018

Summary

Official Symbol
Arcprovided by MGI
Official Full Name
activity regulated cytoskeletal-associated proteinprovided by MGI
Primary source
MGI:MGI:88067
See related
Ensembl:ENSMUSG00000022602 Vega:OTTMUSG00000016386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mArc; Arc3.1; C86064; arg3.1
Expression
Biased expression in testis adult (RPKM 87.3), cortex adult (RPKM 49.3) and 4 other tissues See more
Orthologs

Genomic context

See Arc in Genome Data Viewer
Location:
15 D3; 15 34.25 cM
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (74669081..74672570, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (74499513..74503000, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor B1 Neighboring gene maestro heat-like repeat family member 4 Neighboring gene predicted gene, 32994 Neighboring gene RIKEN cDNA 4933427E11 gene Neighboring gene jerky Neighboring gene prostate stem cell antigen

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Amphetamine addiction, organism-specific biosystem (from KEGG)
    Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • Amphetamine addiction, conserved biosystem (from KEGG)
    Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • Serotonin and anxiety, organism-specific biosystem (from WikiPathways)
    Serotonin and anxiety, organism-specific biosystemBenekareddy et al observed the phenomenon that rats who were maternally separated show increased levels of induced anxiety-related behaviour during adulthood. Type 2 serotonin receptors have been imp...
  • Serotonin and anxiety-related events, organism-specific biosystem (from WikiPathways)
    Serotonin and anxiety-related events, organism-specific biosystem
    Serotonin and anxiety-related events

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
actin binding TAS
Traceable Author Statement
more info
PubMed 
mRNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
endoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-term memory ISO
Inferred from Sequence Orthology
more info
 
mRNA transport ISO
Inferred from Sequence Orthology
more info
 
modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of AMPA receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of AMPA receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of long-term synaptic depression IDA
Inferred from Direct Assay
more info
PubMed 
regulation of long-term synaptic potentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of neuronal synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of postsynaptic neurotransmitter receptor internalization EXP
Inferred from Experiment
more info
PubMed 
regulation of postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle-mediated intercellular transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicle ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic endosome ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
activity-regulated cytoskeleton-associated protein
Names
ARC/ARG3.1
activity-regulated gene 3.1 protein homolog
arc

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276684.1NP_001263613.1  activity-regulated cytoskeleton-associated protein

    See identical proteins and their annotated locations for NP_001263613.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC118022, AK157822
    Consensus CDS
    CCDS37102.1
    UniProtKB/Swiss-Prot
    Q9WV31
    Related
    ENSMUSP00000105636.3, OTTMUSP00000017628, ENSMUST00000110009.3, OTTMUST00000039452
  2. NM_018790.3NP_061260.1  activity-regulated cytoskeleton-associated protein

    See identical proteins and their annotated locations for NP_061260.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC118022, AF162777
    Consensus CDS
    CCDS37102.1
    UniProtKB/Swiss-Prot
    Q9WV31
    Related
    ENSMUSP00000023268.6, OTTMUSP00000021864, ENSMUST00000023268.13, OTTMUST00000047955

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

    Range
    74669081..74672570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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