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Ar androgen receptor [ Mus musculus (house mouse) ]

Gene ID: 11835, updated on 10-Jun-2018
Official Symbol
Arprovided by MGI
Official Full Name
androgen receptorprovided by MGI
Primary source
MGI:MGI:88064
See related
Ensembl:ENSMUSG00000046532 Vega:OTTMUSG00000018072
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tfm; AW320017
Summary
This gene encodes a nuclear hormone receptor containing zinc finger and DNA-binding domains. The encoded protein is a key regulator of signalling by androgens, a class of steroid hormones involved in male reproductive development. The protein responds to hormone signalling by translocating to the nucleus, forming dimers, and binding to androgen response elements (AREs) in the promoters of target genes, which are subsequently transcriptionally activated. Activity of this protein is negatively regulated by nuclear receptor subfamily 0 group B member 1 (Nr0b1, also known as Dax1). Mutations in this gene result in feminized genitals and infertility in male animals. Loss of function in female animals also causes problems in reproductive development and function. [provided by RefSeq, May 2015]
Expression
Biased expression in adrenal adult (RPKM 4.7), genital fat pad adult (RPKM 4.4) and 12 other tissues See more
Orthologs
Location:
X C3; X 42.82 cM
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (98148757..98323218)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (95345089..95512486)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L10 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein M pseudogene Neighboring gene dCMP deaminase pseudogene Neighboring gene oligophrenin 1

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATPase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
POU domain binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
androgen binding ISO
Inferred from Sequence Orthology
more info
 
androgen receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
androgen receptor activity ISO
Inferred from Sequence Orthology
more info
 
androgen receptor binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
ribonucleotide binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
steroid binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Leydig cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of prostate induction by androgen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
animal organ formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular process IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to steroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to testosterone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
copulation ISO
Inferred from Sequence Orthology
more info
 
epithelial cell differentiation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
lateral sprouting involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
male courtship behavior ISO
Inferred from Sequence Orthology
more info
 
male genitalia morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
male gonad development IGI
Inferred from Genetic Interaction
more info
PubMed 
male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
male sex differentiation ISO
Inferred from Sequence Orthology
more info
 
male somatic sex determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
morphogenesis of an epithelial fold IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of integrin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation involved in prostate gland development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of integrin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intracellular estrogen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of penile erection ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
prostate gland epithelium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
prostate gland growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of prostatic bud formation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
regulation of systemic arterial blood pressure IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
reproductive behavior ISO
Inferred from Sequence Orthology
more info
 
reproductive structure development IMP
Inferred from Mutant Phenotype
more info
PubMed 
reproductive system development IGI
Inferred from Genetic Interaction
more info
PubMed 
seminiferous tubule development IGI
Inferred from Genetic Interaction
more info
PubMed 
seminiferous tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
single fertilization IGI
Inferred from Genetic Interaction
more info
PubMed 
skeletal muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
tertiary branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear speck ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IPI
Inferred from Physical Interaction
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
Preferred Names
androgen receptor
Names
dihydrotestosterone receptor
nuclear receptor subfamily 3 group C member 4
testicular feminization

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013476.4NP_038504.1  androgen receptor

    See identical proteins and their annotated locations for NP_038504.1

    Status: REVIEWED

    Source sequence(s)
    AK133647, AL683800, AL844866, M37890
    Consensus CDS
    CCDS30294.1
    UniProtKB/Swiss-Prot
    P19091
    Related
    ENSMUSP00000052648.7, OTTMUSP00000019597, ENSMUST00000052837.8, OTTMUST00000043610
    Conserved Domains (3) summary
    cd07073
    Location:652897
    NR_LBD_AR; Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
    cd07173
    Location:534615
    NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
    pfam02166
    Location:6440
    Androgen_recep; Androgen receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

    Range
    98148757..98323218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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