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Aqp1 aquaporin 1 [ Mus musculus (house mouse) ]

Gene ID: 11826, updated on 22-Jan-2023

Summary

Official Symbol
Aqp1provided by MGI
Official Full Name
aquaporin 1provided by MGI
Primary source
MGI:MGI:103201
See related
Ensembl:ENSMUSG00000004655 AllianceGenome:MGI:103201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CHIP28
Summary
Enables ephrin receptor binding activity; potassium ion transmembrane transporter activity; and water transmembrane transporter activity. Involved in defense response to Gram-negative bacterium and potassium ion transport. Acts upstream of or within several processes, including corticotropin secretion; glomerular filtration; and metanephros development. Located in several cellular components, including basolateral plasma membrane; extracellular exosome; and symbiont-containing vacuole. Is integral component of membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; sensory organ; and skeleton. Orthologous to human AQP1 (aquaporin 1 (Colton blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 483.5), lung adult (RPKM 456.4) and 19 other tissues See more
Orthologs
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Genomic context

See Aqp1 in Genome Data Viewer
Location:
6 B3; 6 27.38 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (55313284..55325540)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (55336299..55348555)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene MINDY lysine 48 deubiquitinase 4 Neighboring gene predicted gene, 38819 Neighboring gene RIKEN cDNA 6430584L05 gene Neighboring gene growth hormone releasing hormone receptor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ammonium transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ammonium transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables carbon dioxide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables carbon dioxide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables channel activity IEA
Inferred from Electronic Annotation
more info
 
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables glycerol transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glycerol transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables intracellular cGMP-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables nitric oxide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables water channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables water channel activity ISO
Inferred from Sequence Orthology
more info
 
enables water channel activity TAS
Traceable Author Statement
more info
PubMed 
enables water transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables water transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ammonium transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in carbon dioxide transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in carbon dioxide transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in carbon dioxide transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell volume homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular hyperosmotic response ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to copper ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to inorganic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mercury ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nitric oxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to salt stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within corticotropin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment of localization in cell IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment or maintenance of actin cytoskeleton polarity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glomerular filtration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycerol transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in hyperosmotic response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular water homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in lateral ventricle development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within lipid digestion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric descending thin limb development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in metanephric glomerulus vasculature development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in metanephric proximal convoluted tubule segment 2 development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in metanephric proximal straight tubule development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nitric oxide transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of saliva secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within renal water absorption IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within renal water absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in renal water transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in renal water transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within secretion by cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within secretory granule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transepithelial water transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within water homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within water transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within water transport IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within water transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in water transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dense core granule membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
aquaporin-1
Names
AQP-1
DER2
aquaporin-CHIP
delayed early response protein 2
growth factor-induced delayed early response protein
water channel protein for red blood cells and kidney proximal tubule
NP_031498.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007472.2NP_031498.1  aquaporin-1

    See identical proteins and their annotated locations for NP_031498.1

    Status: VALIDATED

    Source sequence(s)
    AK081886, BB850287
    Consensus CDS
    CCDS20164.1
    UniProtKB/Swiss-Prot
    Q02013, Q91VY8
    UniProtKB/TrEMBL
    A0A8C6HSP6
    Related
    ENSMUSP00000004774.4, ENSMUST00000004774.4
    Conserved Domains (1) summary
    pfam00230
    Location:4227
    MIP; Major intrinsic protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    55313284..55325540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)