U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Apoh apolipoprotein H [ Mus musculus (house mouse) ]

Gene ID: 11818, updated on 2-Oct-2022

Summary

Official Symbol
Apohprovided by MGI
Official Full Name
apolipoprotein Hprovided by MGI
Primary source
MGI:MGI:88058
See related
Ensembl:ENSMUSG00000000049 AllianceGenome:MGI:88058
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B2GPI; beta2-GPI; beta-2-GPI
Summary
Predicted to enable identical protein binding activity; lipoprotein lipase activator activity; and phospholipid binding activity. Acts upstream of or within regulation of blood coagulation. Located in extracellular space. Is expressed in liver lobe and lung. Human ortholog(s) of this gene implicated in antiphospholipid syndrome; myocardial infarction; and peripheral vascular disease. Orthologous to human APOH (apolipoprotein H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 1780.2), liver adult (RPKM 813.8) and 2 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Apoh in Genome Data Viewer
Location:
11 E1; 11 71.8 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (108286123..108305222)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (108395297..108414396)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene protein kinase C, alpha Neighboring gene predicted gene 11655 Neighboring gene predicted gene, 36709 Neighboring gene centrosomal protein 112 Neighboring gene centrosomal protein 112, opposite strand 1 Neighboring gene predicted gene, 51924

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
 
enables lipoprotein lipase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in animal organ regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in blood coagulation, intrinsic pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of myeloid cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of respiratory burst ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipoprotein lipase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of triglyceride catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
part_of chylomicron ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of very-low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
beta-2-glycoprotein 1
Names
APC inhibitor
activated protein C-binding protein
apo-H
beta(2)GPI
beta-2-glycoprotein I

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013475.4NP_038503.4  beta-2-glycoprotein 1 precursor

    See identical proteins and their annotated locations for NP_038503.4

    Status: VALIDATED

    Source sequence(s)
    AA273732, AK010926, BU756628, BY143138
    Consensus CDS
    CCDS25574.1
    UniProtKB/Swiss-Prot
    Q01339
    UniProtKB/TrEMBL
    Q9CY42
    Related
    ENSMUSP00000000049.6, ENSMUST00000000049.6
    Conserved Domains (4) summary
    cd00033
    Location:84137
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:22260
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:142200
    Sushi; Sushi repeat (SCR repeat)
    pfam09014
    Location:261345
    Sushi_2; Beta-2-glycoprotein-1 fifth domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    108286123..108305222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532042.1XP_006532105.1  beta-2-glycoprotein 1 isoform X1

    Conserved Domains (2) summary
    PHA02927
    Location:22169
    PHA02927; secreted complement-binding protein; Provisional
    pfam09014
    Location:170254
    Sushi_2; Beta-2-glycoprotein-1 fifth domain