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Apoe apolipoprotein E [ Mus musculus (house mouse) ]

Gene ID: 11816, updated on 7-Feb-2023

Summary

Official Symbol
Apoeprovided by MGI
Official Full Name
apolipoprotein Eprovided by MGI
Primary source
MGI:MGI:88057
See related
Ensembl:ENSMUSG00000002985 AllianceGenome:MGI:88057
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Apo-E
Summary
This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related apolipoprotein C1, C2 and C4 genes. [provided by RefSeq, Apr 2015]
Expression
Biased expression in liver adult (RPKM 9050.0), liver E18 (RPKM 4149.1) and 10 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See Apoe in Genome Data Viewer
Location:
7 A3; 7 9.94 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19430169..19434326, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19696244..19701310, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein C2 like Neighboring gene apolipoprotein C-IV Neighboring gene apolipoprotein C-I Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene predicted gene, 38955 Neighboring gene nectin cell adhesion molecule 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables antioxidant activity ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heparan sulfate proteoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heparan sulfate proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables hydroxyapatite binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
enables low-density lipoprotein particle receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables metal chelating activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylcholine-sterol O-acyltransferase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphatidylcholine-sterol O-acyltransferase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables tau protein binding ISO
Inferred from Sequence Orthology
more info
 
enables very-low-density lipoprotein particle receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables very-low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within_positive_effect AMPA glutamate receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within_positive_effect NMDA glutamate receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in aging ISO
Inferred from Sequence Orthology
more info
 
involved_in amyloid precursor protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within artery morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT acts_upstream_of_or_within axon regeneration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cholesterol catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cholesterol homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in chylomicron remnant clearance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within circulatory system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within_negative_effect gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in high-density lipoprotein particle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in high-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in high-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in intermediate-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intracellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in lipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid transport involved in lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipoprotein biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in lipoprotein biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within lipoprotein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipoprotein metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lipoprotein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in locomotory exploration behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in long-chain fatty acid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in long-term memory ISO
Inferred from Sequence Orthology
more info
 
involved_in low-density lipoprotein particle remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maintenance of location in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in melanosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in melanosome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of amyloid fibril formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipid transport across blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phospholipid efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of postsynaptic membrane organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of triglyceride metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation by host of viral process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of CoA-transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of CoA-transferase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of amyloid-beta clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heparan sulfate binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heparan sulfate proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid transport across blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of low-density lipoprotein particle receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurofibrillary tangle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric-oxide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phospholipid efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of presynaptic membrane organization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Cdc42 protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of amyloid-beta clearance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of behavioral fear response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cellular response to very-low-density lipoprotein particle stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of plasma lipoprotein particle levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to caloric restriction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to dietary excess IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in reverse cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride-rich lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in triglyceride-rich lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in very-low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in very-low-density lipoprotein particle remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in very-low-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in virion assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
part_of chylomicron ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
part_of discoidal high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
part_of intermediate-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of intermediate-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
part_of lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
part_of low-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
part_of low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in melanosome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in multivesicular body, internal vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic cleft ISO
Inferred from Sequence Orthology
more info
 
part_of very-low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305819.1NP_001292748.1  apolipoprotein E precursor

    See identical proteins and their annotated locations for NP_001292748.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
    Source sequence(s)
    AI836733, AK134921, DN173921
    Consensus CDS
    CCDS20912.1
    UniProtKB/Swiss-Prot
    P08226
    UniProtKB/TrEMBL
    Q3TXU4
    Related
    ENSMUSP00000133371.2, ENSMUST00000173739.8
    Conserved Domains (1) summary
    pfam01442
    Location:78280
    Apolipoprotein; Apolipoprotein A1/A4/E domain
  2. NM_001305843.1NP_001292772.1  apolipoprotein E precursor

    See identical proteins and their annotated locations for NP_001292772.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC149282, AI836733, AK134921, BY313639, BY772289
    Consensus CDS
    CCDS20912.1
    UniProtKB/Swiss-Prot
    P08226
    UniProtKB/TrEMBL
    Q3TXU4
    Conserved Domains (1) summary
    pfam01442
    Location:78280
    Apolipoprotein; Apolipoprotein A1/A4/E domain
  3. NM_001305844.1NP_001292773.1  apolipoprotein E precursor

    See identical proteins and their annotated locations for NP_001292773.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC149282, AI836733, AK134921
    Consensus CDS
    CCDS20912.1
    UniProtKB/Swiss-Prot
    P08226
    UniProtKB/TrEMBL
    Q3TXU4
    Conserved Domains (1) summary
    pfam01442
    Location:78280
    Apolipoprotein; Apolipoprotein A1/A4/E domain
  4. NM_009696.4NP_033826.2  apolipoprotein E precursor

    See identical proteins and their annotated locations for NP_033826.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
    Source sequence(s)
    AI836733, AK134921, BY313639, BY772289
    Consensus CDS
    CCDS20912.1
    UniProtKB/Swiss-Prot
    P08226
    UniProtKB/TrEMBL
    Q3TXU4
    Related
    ENSMUSP00000133302.2, ENSMUST00000174064.9
    Conserved Domains (1) summary
    pfam01442
    Location:78280
    Apolipoprotein; Apolipoprotein A1/A4/E domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19430169..19434326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242015.2XP_030097875.1  apolipoprotein E isoform X1

    UniProtKB/Swiss-Prot
    P08226
    UniProtKB/TrEMBL
    Q3TXU4
    Conserved Domains (1) summary
    pfam01442
    Location:78280
    Apolipoprotein; Apolipoprotein A1/A4/E domain