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LOC118142757 GUCA1ANB-GUCA1A readthrough [ Homo sapiens (human) ]

Gene ID: 118142757, updated on 26-Oct-2022

Summary

Gene symbol
LOC118142757
Gene description
GUCA1ANB-GUCA1A readthrough
See related
Ensembl:ENSG00000290147
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GUCA1A; GUCA1ANB-GUCA1A
Summary
This locus represents naturally occurring readthrough transcription between the neighboring GUCA1ANB (GUCA1A neighbor) and GUCA1A (guanylate cyclase activator 1A) genes on chromosome 6. The readthrough transcript encodes the same protein as GUCA1A. [provided by RefSeq, Jul 2020]
Orthologs
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Genomic context

See LOC118142757 in Genome Data Viewer
Location:
6p21.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (42155406..42180056)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (41983624..42008260)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42123144..42147794)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 8 Neighboring gene Sharpr-MPRA regulatory region 7068 Neighboring gene chromosome 6 open reading frame 132 Neighboring gene GUCA1A neighbor Neighboring gene guanylate cyclase activator 1A Neighboring gene CRISPRi-validated cis-regulatory element chr6.2919 Neighboring gene guanylate cyclase activator 1B

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Homology

Clone Names

  • FLJ43792, FLJ94498, MGC34591

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium sensitive guanylate cyclase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium sensitive guanylate cyclase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables guanylate cyclase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables guanylate cyclase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phototransduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cGMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of guanylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in visual perception IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cone photoreceptor outer segment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cone photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor disc membrane TAS
Traceable Author Statement
more info
 
is_active_in photoreceptor inner segment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
guanylyl cyclase-activating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000409.5NP_000400.2  guanylyl cyclase-activating protein 1

    See identical proteins and their annotated locations for NP_000400.2

    Status: REVIEWED

    Source sequence(s)
    AL096814
    Consensus CDS
    CCDS4864.1
    UniProtKB/Swiss-Prot
    P43080, Q9NU14
    Conserved Domains (1) summary
    COG5126
    Location:12163
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  2. NM_001319061.2NP_001305990.1  guanylyl cyclase-activating protein 1

    Status: REVIEWED

    Source sequence(s)
    AL096814
    Consensus CDS
    CCDS4864.1
    UniProtKB/Swiss-Prot
    P43080, Q9NU14
    Conserved Domains (1) summary
    COG5126
    Location:12163
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  3. NM_001319062.2NP_001305991.1  guanylyl cyclase-activating protein 1

    Status: REVIEWED

    Source sequence(s)
    AL096814
    Consensus CDS
    CCDS4864.1
    UniProtKB/Swiss-Prot
    P43080, Q9NU14
    UniProtKB/TrEMBL
    B2R9P6
    Related
    ENSP00000499539.1, ENST00000654459.1
    Conserved Domains (1) summary
    COG5126
    Location:12163
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    42155406..42180056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    41983624..42008260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)