Apoc1 apolipoprotein C-I [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Apoc1provided by MGI
Official Full Name: apolipoprotein C-Iprovided by MGI
Primary source: MGI:MGI:88053
See related: Ensembl:ENSMUSG00000040564 AllianceGenome:MGI:88053
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: apo-CI; apoC-I; Apo-CIB; ApoC-IB
Summary: This gene encodes a precursor plasma protein that is cleaved to yield a signal peptide and two alternatively processed mature peptides. The encoded protein, which is a component of chylomicrons, very low density lipoproteins and high density lipoproteins, transports lipids from the intestines to other locations in the body. This protein binds to free fatty acids preventing their uptake by cells. This protein is a cofactor for lecithin cholesterol acyltransferase, an enzyme that catalyzes the conversion of free cholesterol to cholesteryl esters. The encoded protein inhibits the activity of the cholesteryl ester transfer protein which promotes the exchange of neutral lipids between lipoproteins. In humans this gene is associated with risk of coronary artery disease and age-associated memory impairment. Mice lacking this gene demonstrate impaired memory. This gene is clustered with three other apolipoprotein genes on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression: Biased expression in liver adult (RPKM 1389.4) and liver E18 (RPKM 245.3) See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 9.94 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (19423405..19426584, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19689480..19692659, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing.
Title: Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing.
APOC1 expression induces glomerulosclerosis, potentially by increasing the cytokine response in macrophages.
Title: Apolipoprotein C-I plays a role in the pathogenesis of glomerulosclerosis.
Apolipoprotein C-I was significantly increased in obese mice plasma.
Title: Secretome-derived isotope tags (SDIT) reveal adipocyte-derived apolipoprotein C-I as a predictive marker for cardiovascular disease.
The absence of ApoC-I results in impaired memory functions, which is, together with previous data, suggestive of an important, bell-shaped gene-dose dependent role for ApoC-I in appropriate brain functioning
Title: Apolipoprotein CI knock-out mice display impaired memory functions.
Data show that the stimulating effect of apoCI on the lipopolysaccharide (LPS)response resembles that of LPS-binding protein (LBP) and depends on CD14/ Toll-like receptor 4 signaling.
Title: Apolipoprotein CI enhances the biological response to LPS via the CD14/TLR4 pathway by LPS-binding elements in both its N- and C-terminal helix.
apoCI is a novel inhibitor of the scavenger receptor BI -mediated uptake of HDL cholesterol by hepatocytes; apoCI is a determinant for the plasma levels and size of HDL in vivo.
Title: Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo.
Systemic apoCI increases atherosclerosis, probably by inducing hyperlipidemia, in the absence of ApoE
Title: Apolipoprotein CI aggravates atherosclerosis development in ApoE-knockout mice despite mediating cholesterol efflux from macrophages.
apoCI is crucially involved in lipopolysaccharide(LPS)-induced atherosclerosis in apoe-/- mice, which mainly relates to an increased inflammatory response toward LPS
Title: Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice.
Data suggest that apoC-I binds free fatty acids (FFA), thereby reducing the blood FFA for uptake by cells, and this mechanism can serve as an additional mechanism for the resistance to obesity and the cutaneous abnormalities of APOC1(+/+) mice.
Title: Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification.
The apoC-I content of lipoprotein remnants may serve as an early marker of coronary artery disease risk.
Title: Postprandial enrichment of remnant lipoproteins with apoC-I in healthy normolipidemic men with early asymptomatic atherosclerosis.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Homology

Orthologs from Annotation Pipeline: 255 organisms have orthologs with human gene Apoc1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables lipase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables phospholipase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables phospholipase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chylomicron remnant clearance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipoprotein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cholesterol transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of lipoprotein lipase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylcholine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of very-low-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of very-low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in plasma lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid transport	ISO Inferred from Sequence Orthology more info
involved_in triglyceride metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in very-low-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in very-low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
part_of high-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apolipoprotein C-I

Names: apolipoprotein C1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110009.2 → NP_001103479.1 apolipoprotein C-I precursor

See identical proteins and their annotated locations for NP_001103479.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC149282, BC094638

Consensus CDS

CCDS39802.1

UniProtKB/Swiss-Prot

P34928, Q505B2

Related

ENSMUSP00000045571.5, ENSMUST00000045035.12

Conserved Domains (1) summary

pfam04691
Location:27 → 86

ApoC-I; Apolipoprotein C-I (ApoC-1)
NM_007469.5 → NP_031495.1 apolipoprotein C-I precursor

See identical proteins and their annotated locations for NP_031495.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC149282, AK011358

Consensus CDS

CCDS39802.1

UniProtKB/Swiss-Prot

P34928, Q505B2

Related

ENSMUSP00000104091.3, ENSMUST00000108451.4

Conserved Domains (1) summary

pfam04691
Location:27 → 86

ApoC-I; Apolipoprotein C-I (ApoC-1)