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Apoc1 apolipoprotein C-I [ Mus musculus (house mouse) ]

Gene ID: 11812, updated on 9-Oct-2022

Summary

Official Symbol
Apoc1provided by MGI
Official Full Name
apolipoprotein C-Iprovided by MGI
Primary source
MGI:MGI:88053
See related
Ensembl:ENSMUSG00000040564 AllianceGenome:MGI:88053
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
apo-CI; apoC-I; Apo-CIB; ApoC-IB
Summary
This gene encodes a precursor plasma protein that is cleaved to yield a signal peptide and two alternatively processed mature peptides. The encoded protein, which is a component of chylomicrons, very low density lipoproteins and high density lipoproteins, transports lipids from the intestines to other locations in the body. This protein binds to free fatty acids preventing their uptake by cells. This protein is a cofactor for lecithin cholesterol acyltransferase, an enzyme that catalyzes the conversion of free cholesterol to cholesteryl esters. The encoded protein inhibits the activity of the cholesteryl ester transfer protein which promotes the exchange of neutral lipids between lipoproteins. In humans this gene is associated with risk of coronary artery disease and age-associated memory impairment. Mice lacking this gene demonstrate impaired memory. This gene is clustered with three other apolipoprotein genes on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression
Biased expression in liver adult (RPKM 1389.4) and liver E18 (RPKM 245.3) See more
Orthologs
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Genomic context

See Apoc1 in Genome Data Viewer
Location:
7 A3; 7 9.94 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19423405..19426584, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19689480..19692659, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein C2 like Neighboring gene apolipoprotein C2 Neighboring gene apolipoprotein C-IV Neighboring gene apolipoprotein E Neighboring gene translocase of outer mitochondrial membrane 40

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
enables lipase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chylomicron remnant clearance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipoprotein lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of lipoprotein lipase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphatidylcholine catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of very-low-density lipoprotein particle clearance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of very-low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in plasma lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in very-low-density lipoprotein particle clearance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in very-low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
part_of high-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
part_of very-low-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of very-low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
apolipoprotein C-I
Names
apolipoprotein C1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110009.2NP_001103479.1  apolipoprotein C-I precursor

    See identical proteins and their annotated locations for NP_001103479.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC149282, BC094638
    Consensus CDS
    CCDS39802.1
    UniProtKB/Swiss-Prot
    P34928, Q505B2
    Related
    ENSMUSP00000045571.5, ENSMUST00000045035.12
    Conserved Domains (1) summary
    pfam04691
    Location:2786
    ApoC-I; Apolipoprotein C-I (ApoC-1)
  2. NM_007469.5NP_031495.1  apolipoprotein C-I precursor

    See identical proteins and their annotated locations for NP_031495.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC149282, AK011358
    Consensus CDS
    CCDS39802.1
    UniProtKB/Swiss-Prot
    P34928, Q505B2
    Related
    ENSMUSP00000104091.3, ENSMUST00000108451.4
    Conserved Domains (1) summary
    pfam04691
    Location:2786
    ApoC-I; Apolipoprotein C-I (ApoC-1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    19423405..19426584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)