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Apoa1 apolipoprotein A-I [ Mus musculus (house mouse) ]

Gene ID: 11806, updated on 4-Jun-2024

Summary

Official Symbol
Apoa1provided by MGI
Official Full Name
apolipoprotein A-Iprovided by MGI
Primary source
MGI:MGI:88049
See related
Ensembl:ENSMUSG00000032083 AllianceGenome:MGI:88049
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sep2; Alp-1; Ltw-1; Sep-1; Sep-2; Apoa-1; Brp-14; Lvtw-1; apo-AI; apoA-I
Summary
This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is the major protein component of plasma high density lipoprotein (HDL). This protein facilitates the removal of cholesterol and other fats from tissues by transporting them to the liver for excretion. This protein is a cofactor for lecithin cholesterolacyltransferase, an enzyme that catalyzes the conversion of free cholesterol to cholesteryl esters. Mutations in this gene in humans causes familial HDL deficiency, Tangier disease and familial visceral amyloidosis. Similar clinical features are exhibited by mice with mutations in this gene. This gene is clustered with three other apolipoprotein genes on chromosome 9. [provided by RefSeq, Dec 2013]
Expression
Biased expression in liver E18 (RPKM 4031.2), duodenum adult (RPKM 3636.0) and 7 other tissues See more
Orthologs
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Genomic context

See Apoa1 in Genome Data Viewer
Location:
9 A5.2; 9 25.36 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (46139928..46141767)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (46228630..46230469)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24013 Neighboring gene STARR-seq mESC enhancer starr_24014 Neighboring gene predicted gene, 46110 Neighboring gene SIK family kinase 3 Neighboring gene STARR-seq mESC enhancer starr_24018 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45928283-45928392 Neighboring gene POU domain, class 5, transcription factor 1, related sequence 9 Neighboring gene STARR-seq mESC enhancer starr_24022 Neighboring gene apolipoprotein C-III Neighboring gene apolipoprotein A-IV

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102525

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables apolipoprotein A-I receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables apolipoprotein receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables chemorepellent activity ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cholesterol transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to cholesterol transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables high-density lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
enables high-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylcholine-sterol O-acyltransferase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylcholine-sterol O-acyltransferase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in acylglycerol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within adrenal gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in animal organ regeneration ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within axon regeneration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cholesterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol efflux IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol import ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cholesterol metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cholesterol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cholesterol transport ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucocorticoid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in high-density lipoprotein particle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in high-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipoprotein biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lipoprotein biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion molecule production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytokine production involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of hydrolase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of very-low-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-methionine modification ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylcholine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid efflux IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipid efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of CoA-transferase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phospholipid efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Cdc42 protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of intestinal cholesterol absorption IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in reverse cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in vitamin transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
part_of chylomicron IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of discoidal high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of high-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
part_of intermediate-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
part_of low-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
part_of spherical high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
part_of very-low-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of very-low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
apolipoprotein A-I
Names
apolipoprotein A1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009692.4NP_033822.2  apolipoprotein A-I preproprotein

    See identical proteins and their annotated locations for NP_033822.2

    Status: REVIEWED

    Source sequence(s)
    AC116503, AK076187
    Consensus CDS
    CCDS40610.1
    UniProtKB/Swiss-Prot
    O08855, O09042, Q00623, Q8BPD5
    UniProtKB/TrEMBL
    Q3V2G1
    Related
    ENSMUSP00000034588.9, ENSMUST00000034588.9
    Conserved Domains (2) summary
    pfam01442
    Location:73240
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam02601
    Location:147206
    Exonuc_VII_L; Exonuclease VII, large subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    46139928..46141767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)