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Birc5 baculoviral IAP repeat-containing 5 [ Mus musculus (house mouse) ]

Gene ID: 11799, updated on 8-Dec-2022

Summary

Official Symbol
Birc5provided by MGI
Official Full Name
baculoviral IAP repeat-containing 5provided by MGI
Primary source
MGI:MGI:1203517
See related
Ensembl:ENSMUSG00000017716 AllianceGenome:MGI:1203517
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Api4; TIAP; AAC-11; survivin40
Summary
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver E14 (RPKM 37.4), liver E14.5 (RPKM 32.6) and 13 other tissues See more
Orthologs
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Genomic context

See Birc5 in Genome Data Viewer
Location:
11; 11 E2
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117740063..117746569)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117849237..117855743)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene synaptogyrin 2 Neighboring gene thymidine kinase 1 Neighboring gene arylformamidase Neighboring gene VISTA enhancer mm780 Neighboring gene transmembrane protein 235 Neighboring gene predicted gene 11725 Neighboring gene threonine aldolase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of chromosome localization ISO
Inferred from Sequence Orthology
more info
 
involved_in meiosis I IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cytokinesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle midzone assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitotic spindle organization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of exit from mitosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of mitotic cytokinesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of mitotic sister chromatid separation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein-containing complex localization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of type B pancreatic cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in centriole ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
part_of chromosome passenger complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in interphase microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
 
part_of survivin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
baculoviral IAP repeat-containing protein 5
Names
apoptosis inhibitor 4
apoptosis inhibitor survivin
survivin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012273.1NP_001012273.1  baculoviral IAP repeat-containing protein 5 isoform 3

    See identical proteins and their annotated locations for NP_001012273.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as survivin121, uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform 3 which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB013819, BC004702, BY023910
    Consensus CDS
    CCDS25695.1
    UniProtKB/Swiss-Prot
    O70201
    Related
    ENSMUSP00000091433.5, ENSMUST00000093906.5
    Conserved Domains (1) summary
    pfam00653
    Location:1888
    BIR; Inhibitor of Apoptosis domain
  2. NM_009689.2NP_033819.1  baculoviral IAP repeat-containing protein 5 isoform 1

    See identical proteins and their annotated locations for NP_033819.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as survivin140, represents the most frequently occurring transcript and it encodes isoform 1.
    Source sequence(s)
    AB013819, AI413910, CN724527
    Consensus CDS
    CCDS25694.1
    UniProtKB/Swiss-Prot
    O70201, Q9WU54
    UniProtKB/TrEMBL
    Q549P2
    Related
    ENSMUSP00000079124.5, ENSMUST00000081387.11
    Conserved Domains (1) summary
    pfam00653
    Location:1888
    BIR; Inhibitor of Apoptosis domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    117740063..117746569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001012272.1: Suppressed sequence

    Description
    NM_001012272.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.