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Xiap X-linked inhibitor of apoptosis [ Mus musculus (house mouse) ]

Gene ID: 11798, updated on 8-Feb-2024

Summary

Official Symbol
Xiapprovided by MGI
Official Full Name
X-linked inhibitor of apoptosisprovided by MGI
Primary source
MGI:MGI:107572
See related
Ensembl:ENSMUSG00000025860 AllianceGenome:MGI:107572
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aipa; Api3; IAP3; MIHA; Birc4; ILP-1; 1110015C02Rik
Summary
The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) family of proteins. While first identified for its role in blocking apoptosis, this protein modulates many other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. This protein blocks apoptosis by binding and inhibiting target caspases after they have been activated. Binding occurs to some, but not all, caspases. This protein has several conserved regions, including baculoviral IAP repeat (BIR) motifs and a RING finger E3 ligase domain. In humans, mutations in this gene are linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). A pseudogene of this gene is found on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Expression
Ubiquitous expression in cerebellum adult (RPKM 7.1), bladder adult (RPKM 6.9) and 26 other tissues See more
Orthologs
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Genomic context

See Xiap in Genome Data Viewer
Location:
X A4; X 23.19 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (41148483..41198541)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (42059613..42109664)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47056 Neighboring gene N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits pseudogene Neighboring gene ribosomal protein S7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47057 Neighboring gene STARR-seq mESC enhancer starr_47058 Neighboring gene STARR-seq mESC enhancer starr_47060 Neighboring gene STARR-positive B cell enhancer ABC_E9459 Neighboring gene zinc finger protein 7 pseudogene Neighboring gene STAG2 cohesin complex component

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables endopeptidase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inhibition of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of apoptosis involved in tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase XIAP
Names
IAP homolog A
RING-type E3 ubiquitin transferase XIAP
X-linked IAP
baculoviral IAP repeat-containing protein 4
inhibitor of apoptosis protein 3
NP_001288568.1
NP_001288570.1
NP_033818.2
XP_006541488.1
XP_006541490.1
XP_011249278.1
XP_011249279.1
XP_017173848.1
XP_017173849.1
XP_017173850.1
XP_017173851.1
XP_030107060.1
XP_030107062.1
XP_030107063.1
XP_036017678.1
XP_036017679.1
XP_036017680.1
XP_036017681.1
XP_036017682.1
XP_036017683.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301639.1NP_001288568.1  E3 ubiquitin-protein ligase XIAP

    See identical proteins and their annotated locations for NP_001288568.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AI848625, AK041844, AK147447, BC138528, BG091082, CD548741, CK389763, CN527460, CN535777
    Consensus CDS
    CCDS30098.1
    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Related
    ENSMUSP00000110747.3, ENSMUST00000115095.9
    Conserved Domains (4) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  2. NM_001301641.1NP_001288570.1  E3 ubiquitin-protein ligase XIAP

    See identical proteins and their annotated locations for NP_001288570.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AI848625, AK041844, AK147447, BC138528, BG091082, BX530028, CD548741, CK389763, CN527460, CN535777
    Consensus CDS
    CCDS30098.1
    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Related
    ENSMUSP00000061074.4, ENSMUST00000055483.10
    Conserved Domains (4) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  3. NM_009688.3NP_033818.2  E3 ubiquitin-protein ligase XIAP

    See identical proteins and their annotated locations for NP_033818.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AI848625, AK041844, AK147447, BC138528, BG091082, CD548741, CJ111937, CJ126958, CK389763, CN527460, CN535777
    Consensus CDS
    CCDS30098.1
    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Related
    ENSMUSP00000110746.2, ENSMUST00000115094.8
    Conserved Domains (4) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

RNA

  1. NR_125870.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AI848625, AK041844, AK147447, BB663325, BC138528, BG091082, CD548741, CK389763, CN527460, CN535777
    Related
    ENSMUST00000145065.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    41148483..41198541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318359.3XP_017173848.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  2. XM_017318362.3XP_017173851.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  3. XM_017318360.3XP_017173849.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  4. XM_030251203.2XP_030107063.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  5. XM_036161787.1XP_036017680.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  6. XM_036161786.1XP_036017679.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  7. XM_030251202.2XP_030107062.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  8. XM_036161788.1XP_036017681.1  E3 ubiquitin-protein ligase XIAP isoform X3

    Conserved Domains (3) summary
    smart00238
    Location:214284
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:80147
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:421470
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  9. XM_011250976.4XP_011249278.1  E3 ubiquitin-protein ligase XIAP isoform X1

    Conserved Domains (4) summary
    smart00238
    Location:214284
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:80147
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:421470
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:487548
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  10. XM_036161790.1XP_036017683.1  E3 ubiquitin-protein ligase XIAP isoform X4

    Conserved Domains (3) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  11. XM_017318361.2XP_017173850.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  12. XM_006541427.3XP_006541490.1  E3 ubiquitin-protein ligase XIAP isoform X2

    See identical proteins and their annotated locations for XP_006541490.1

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  13. XM_006541425.3XP_006541488.1  E3 ubiquitin-protein ligase XIAP isoform X2

    See identical proteins and their annotated locations for XP_006541488.1

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  14. XM_036161785.1XP_036017678.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  15. XM_030251200.2XP_030107060.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  16. XM_036161789.1XP_036017682.1  E3 ubiquitin-protein ligase XIAP isoform X4

    Conserved Domains (3) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
  17. XM_011250977.4XP_011249279.1  E3 ubiquitin-protein ligase XIAP isoform X2

    See identical proteins and their annotated locations for XP_011249279.1

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:2895
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins