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Ap2a2 adaptor-related protein complex 2, alpha 2 subunit [ Mus musculus (house mouse) ]

Gene ID: 11772, updated on 27-Nov-2024

Summary

Official Symbol
Ap2a2provided by MGI
Official Full Name
adaptor-related protein complex 2, alpha 2 subunitprovided by MGI
Primary source
MGI:MGI:101920
See related
Ensembl:ENSMUSG00000002957 AllianceGenome:MGI:101920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L25; Adtab; 2410074K14Rik
Summary
Enables disordered domain specific binding activity and protein kinase binding activity. Involved in clathrin-dependent endocytosis and synaptic vesicle endocytosis. Located in cytoplasmic vesicle. Part of AP-2 adaptor complex. Is expressed in brain. Orthologous to human AP2A2 (adaptor related protein complex 2 subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 33.9), duodenum adult (RPKM 33.3) and 28 other tissues See more
Orthologs
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Genomic context

See Ap2a2 in Genome Data Viewer
Location:
7 F5; 7 86.94 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141142093..141212924)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141562180..141633011)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11377 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L Neighboring gene tetraspanin 4 Neighboring gene chitinase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_20492 Neighboring gene STARR-seq mESC enhancer starr_20493 Neighboring gene STARR-positive B cell enhancer ABC_E2855 Neighboring gene predicted gene, 16982 Neighboring gene microRNA 7063 Neighboring gene mucin 6, gastric Neighboring gene mucin 2 Neighboring gene mucin 5, subtypes A and C, tracheobronchial/gastric

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables clathrin adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables disordered domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of AP-2 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of AP-2 adaptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of AP-2 adaptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of AP-2 adaptor complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
part_of membrane coat IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
located_in secretory granule TAS
Traceable Author Statement
more info
PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
AP-2 complex subunit alpha-2
Names
100 kDa coated vesicle protein C
adapter-related protein complex 2 alpha-2 subunit
adapter-related protein complex 2 subunit alpha-2
adaptor protein complex AP-2 subunit alpha-2
adaptor protein complex AP-2, alpha 2 subunit
adaptor-related protein complex 2 subunit alpha-2
adaptor-related protein complex AP-2, alpha 2 subunit
alpha-C adaptin
alpha-adaptin C
alpha2-adaptin
clathrin assembly protein complex 2 alpha-C large chain
plasma membrane adaptor HA2/AP2 adaptin alpha C subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357068.1NP_001343997.1  AP-2 complex subunit alpha-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC102524, AC158224
    UniProtKB/TrEMBL
    Q6PEE6
    Conserved Domains (4) summary
    smart00809
    Location:717820
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332355
    HEAT; HEAT repeat [structural motif]
    pfam02296
    Location:826934
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29591
    Adaptin_N; Adaptin N terminal region
  2. NM_007459.3NP_031485.3  AP-2 complex subunit alpha-2 isoform 2

    See identical proteins and their annotated locations for NP_031485.3

    Status: VALIDATED

    Source sequence(s)
    AK173054, BC058099, BY729047
    Consensus CDS
    CCDS40188.1
    UniProtKB/Swiss-Prot
    P17427, Q8C2J5, Q921V0
    UniProtKB/TrEMBL
    Q6PEE6
    Related
    ENSMUSP00000003038.9, ENSMUST00000003038.12
    Conserved Domains (4) summary
    smart00809
    Location:716819
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:331354
    HEAT; HEAT repeat [structural motif]
    pfam02296
    Location:825933
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29590
    Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141142093..141212924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)