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Ap1m1 adaptor-related protein complex AP-1, mu subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 11767, updated on 8-Mar-2025

Summary

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Official Symbol
Ap1m1provided by MGI
Official Full Name
adaptor-related protein complex AP-1, mu subunit 1provided by MGI
Primary source
MGI:MGI:102776
See related
Ensembl:ENSMUSG00000003033 AllianceGenome:MGI:102776
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AP47; mu1A; Cltnm; Adtm1A
Summary
This gene encodes the mu-1 subunit of the scaffolding adapter protein complex AP-1 and is a member of the mu adaptin family. The AP-1 complex, which consists of 4 subunits (mu-adaptin, beta-prime adaptin, gamma-adaptin, and the small chain adaptin), is one of the predominant coat proteins of membrane vesicles involved in eukaryotic post-Golgi trafficking. The AP-1 complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. AP-1 complex subunit mu-1 and other mu-adaptins select cargo proteins bearing sequence-specific sorting motifs. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in testis adult (RPKM 143.4), whole brain E14.5 (RPKM 62.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ap1m1 in Genome Data Viewer
Location:
8 B3.3; 8 34.92 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72993857..73011230)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72240013..72257386)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene calcium and integrin binding family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E9026 Neighboring gene family with sequence similarity 32, member A Neighboring gene STARR-positive B cell enhancer ABC_E2266 Neighboring gene predicted gene, 51536 Neighboring gene STARR-positive B cell enhancer ABC_E5019 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:74802980-74803318 Neighboring gene predicted gene, 51537 Neighboring gene predicted gene, 39197

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The adaptor protein-1 μ1B subunit expands the repertoire of basolateral sorting signal recognition in epithelial cells. Guo X, et al. Dev Cell, 2013 Nov 11. PMID 24229647, Free PMC Article
  2. Adaptor proteins involved in polarized sorting. Bonifacino JS. J Cell Biol, 2014 Jan 6. PMID 24395635, Free PMC Article
  3. AP-1A controls secretory granule biogenesis and trafficking of membrane secretory granule proteins. Bonnemaison M, et al. Traffic, 2014 Oct. PMID 25040637, Free PMC Article
  4. Mu 1A deficiency induces a profound increase in MPR300/IGF-II receptor internalization rate. Meyer C, et al. J Cell Sci, 2001 Dec. PMID 11792812
  5. The cytoplasmic tail of L-selectin interacts with the adaptor-protein complex AP-1 subunit μ1A via a novel basic binding motif. Dib K, et al. J Biol Chem, 2017 Apr 21. PMID 28235798, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endosome to melanosome transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endosome to melanosome transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intracellular protein transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in melanosome assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in melanosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in platelet dense granule organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within vesicle-mediated transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-1 adaptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome NAS
Non-traceable Author Statement
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network TAS
Traceable Author Statement
more info
 PubMed 
located_in trans-Golgi network membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
AP-1 complex subunit mu-1
Names
AP-mu chain family member mu1A
adapter-related protein complex 1 subunit mu-1
adaptor protein complex AP-1 mu-1 subunit
adaptor-related protein complex 1 mu-1 subunit
clathrin assembly protein complex 1 medium chain 1
clathrin assembly protein complex 1 mu-1 medium chain 1
clathrin coat assembly protein AP47
clathrin coat-associated protein AP47
golgi adaptor HA1/AP1 adaptin mu-1 subunit
mu-adaptin 1
mu1A-adaptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007456.5 → NP_031482.1  AP-1 complex subunit mu-1

    See identical proteins and their annotated locations for NP_031482.1

    Status: REVIEWED

    Source sequence(s)
    AC158898, AK148173, CJ075420, CX240144
    Consensus CDS
    CCDS22411.1
    UniProtKB/Swiss-Prot
    P35585
    UniProtKB/TrEMBL
    Q3UG16
    Related
    ENSMUSP00000003117.9, ENSMUST00000003117.15
    Conserved Domains (2) summary
    cd09258
    Location:153 → 422
    AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1
    cd14835
    Location:4 → 142
    AP1_Mu_N; AP-1 complex subunit mu N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    72993857..73011230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509538.4 → XP_006509601.1  AP-1 complex subunit mu-1 isoform X1

    Conserved Domains (2) summary
    cd09258
    Location:127 → 396
    AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1
    cd14835
    Location:1 → 116
    AP1_Mu_N; AP-1 complex subunit mu N-terminal domain

  2. XM_030243252.2 → XP_030099112.1  AP-1 complex subunit mu-1 isoform X1

    Conserved Domains (2) summary
    cd09258
    Location:127 → 396
    AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1
    cd14835
    Location:1 → 116
    AP1_Mu_N; AP-1 complex subunit mu N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35585.3 GenPept UniProtKB/Swiss-Prot:P35585

Gene LinkOut

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