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Anxa8 annexin A8 [ Mus musculus (house mouse) ]

Gene ID: 11752, updated on 8-Jan-2023

Summary

Official Symbol
Anxa8provided by MGI
Official Full Name
annexin A8provided by MGI
Primary source
MGI:MGI:1201374
See related
Ensembl:ENSMUSG00000021950 AllianceGenome:MGI:1201374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Anx8
Summary
Predicted to enable several functions, including actin filament binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Predicted to be involved in endosomal transport; endosome organization; and negative regulation of hydrolase activity. Predicted to act upstream of or within blood coagulation. Predicted to be located in cytosol; late endosome membrane; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including foregut; forelimb; genitourinary system; sensory organ; and skin. Orthologous to several human genes including ANXA8L1 (annexin A8 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 12.6), placenta adult (RPKM 6.3) and 10 other tissues See more
Orthologs
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Genomic context

See Anxa8 in Genome Data Viewer
Location:
14 B; 14 20.8 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33807936..33822528)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34085979..34100571)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30083 Neighboring gene predicted gene 5460 Neighboring gene RIKEN cDNA A630023A22 gene Neighboring gene anthrax toxin receptor-like Neighboring gene predicted gene, 24998 Neighboring gene predicted gene, 30556

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC40628

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
 
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
annexin A8
Names
annexin 8
annexin VIII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281845.1NP_001268774.1  annexin A8 isoform 2

    See identical proteins and their annotated locations for NP_001268774.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC164099, AJ002390, AK009085, AK075870
    Consensus CDS
    CCDS70565.1
    UniProtKB/Swiss-Prot
    O35640
    UniProtKB/TrEMBL
    Q921D0
    Related
    ENSMUSP00000113662.2, ENSMUST00000120077.2
    Conserved Domains (1) summary
    pfam00191
    Location:2690
    Annexin; Annexin
  2. NM_013473.4NP_038501.2  annexin A8 isoform 1

    See identical proteins and their annotated locations for NP_038501.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC164099, AJ002390, AK009085, AK075870
    Consensus CDS
    CCDS26932.1
    UniProtKB/Swiss-Prot
    O35640, Q8K2N9
    UniProtKB/TrEMBL
    A0A6P5QZY5, A0A8C6H4I6
    Related
    ENSMUSP00000022519.9, ENSMUST00000022519.15
    Conserved Domains (1) summary
    pfam00191
    Location:2690
    Annexin; Annexin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    33807936..33822528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)