Anxa7 annexin A7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Anxa7provided by MGI
Official Full Name: annexin A7provided by MGI
Primary source: MGI:MGI:88031
See related: Ensembl:ENSMUSG00000021814 AllianceGenome:MGI:88031
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Anx7; synexin
Summary: Predicted to enable several functions, including calcium-dependent phospholipid binding activity; calcium-dependent protein binding activity; and integrin binding activity. Acts upstream of or within several processes, including cellular chemical homeostasis; hemostasis; and response to salt stress. Located in several cellular components, including cytosol; nuclear envelope; and vesicle. Orthologous to human ANXA7 (annexin A7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 48.4), bladder adult (RPKM 40.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A3; 14 11.53 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (20505329..20530268, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (20455261..20480133, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANXA7 Regulates Platelet Lipid Metabolism and Ca(2+) Release in Arterial Thrombosis.
Title: ANXA7 Regulates Platelet Lipid Metabolism and Ca(2+) Release in Arterial Thrombosis.
ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration.
Title: ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration.
Long Noncoding RNAs Coregulated by Annexin A7 and JNK in Hepatocellular Carcinoma Cells Identified by Whole-Genome Expression Profiling.
Title: Long Noncoding RNAs Coregulated by Annexin A7 and JNK in Hepatocellular Carcinoma Cells Identified by Whole-Genome Expression Profiling.
AnnexinA7 positively regulates expression levels of SDF1/CXCR4
Title: High co-expression of the SDF1/CXCR4 axis in hepatocarcinoma cells is regulated by AnnexinA7 in vitro and in vivo.
Study demonstrates that annexin A7 protein has an important role in gastric cancer. Silencing the expression of ANXA7 in vitro and in vivo induces the apoptosis of BGC823 gastric cancer cells and, importantly, inhibits the growth of tumor xenografts in mice.
Title: Effect of annexin A7 suppression on the apoptosis of gastric cancer cells.
Annexin A7 deficiency upregulates FGF23 plasma levels, an effect paralleled by increased corticosterone plasma levels, as well as decreased 1,25(OH)2 D3 and PTH plasma levels.
Title: Impact of Annexin A 7 Deficiency on FGF23 Plasma Concentrations.
alterations in serum Annexin A7 expression may be of prognostic relevance in hepatocarcinoma lymphatic metastasis
Title: In vivo and in vitro effect of hepatocarcinoma lymph node metastasis by upregulation of Annexin A7 and relevant mechanisms.
Ezrin may play a role in regulating lymphatic metastasis in hepatocellular carcinoma and might be inversely associated with A7 expression.
Title: Ezrin expression is altered in mice lymphatic metastatic hepatocellular carcinoma and subcellular fractions upon Annexin 7 modulation in-vitro.
Annexin A7 formed a protein complex with BAG4 in mouse hepatocarcinoma cells; Annexin A7 modulated BAG4 and BAG4-binding proteins in mitochondrial apoptosis.
Title: Annexin A7 modulates BAG4 and BAG4-binding proteins in mitochondrial apoptosis.
Decreased expression of Annexin A7 inhibits the proliferation of hepatocarcinoma cells by way of the intrinsic mitochoindrial pathway.
Title: Down-regulated expression of Annexin A7 induces apoptosis in mouse hepatocarcinoma cell line by the intrinsic mitochondrial pathway.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Anxa7 (e-PCR), detects polymorphism
- UniSTS:141089

RH128488 (e-PCR)
- UniSTS:211796

AI265384 (e-PCR)
- UniSTS:160365

AI316497 (e-PCR)
- UniSTS:180614

Homology

Homologs of the Anxa7 gene: The Anxa7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, fruit fly, C.elegans, M.oryzae, N.crassa, and frog.
Orthologs from Annotation Pipeline: 340 organisms have orthologs with human gene Anxa7
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of establishment of localization in cell	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of insulin secretion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular water homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect ion channel modulating, G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect ligand-gated ion channel signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane fusion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with chromaffin granule membrane	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: annexin A7

Names: annexin VII; annexin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110794.1 → NP_001104264.1 annexin A7 isoform 1

See identical proteins and their annotated locations for NP_001104264.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate splice site which results in a shorter 5' UTR, as compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK134589, AK169199, CJ163805

Consensus CDS

CCDS26845.1

UniProtKB/Swiss-Prot

Q07076, Q3TT33

UniProtKB/TrEMBL

Q3UYL7

Related

ENSMUSP00000066035.10, ENSMUST00000065504.17

Conserved Domains (1) summary

pfam00191
Location:164 → 229

Annexin; Annexin
NM_001374757.1 → NP_001361686.1 annexin A7 isoform 3

Status: VALIDATED

Source sequence(s)

AC121801

Consensus CDS

CCDS88585.1

UniProtKB/TrEMBL

A0A2C9F2D2

Conserved Domains (1) summary

pfam00191
Location:186 → 251

Annexin
NM_009674.3 → NP_033804.2 annexin A7 isoform 1

See identical proteins and their annotated locations for NP_033804.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK032013, AK134589, AK169199, CJ163805

Consensus CDS

CCDS26845.1

UniProtKB/Swiss-Prot

Q07076, Q3TT33

UniProtKB/TrEMBL

Q3UYL7, Q8CCV9

Related

ENSMUSP00000153669.2, ENSMUST00000224975.2

Conserved Domains (1) summary

pfam00191
Location:164 → 229

Annexin; Annexin