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Anxa7 annexin A7 [ Mus musculus (house mouse) ]

Gene ID: 11750, updated on 12-Feb-2024

Summary

Official Symbol
Anxa7provided by MGI
Official Full Name
annexin A7provided by MGI
Primary source
MGI:MGI:88031
See related
Ensembl:ENSMUSG00000021814 AllianceGenome:MGI:88031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Anx7; synexin
Summary
Predicted to enable several functions, including calcium-dependent phospholipid binding activity; calcium-dependent protein binding activity; and integrin binding activity. Acts upstream of or within several processes, including cellular chemical homeostasis; hemostasis; and response to salt stress. Located in several cellular components, including cytosol; nuclear envelope; and vesicle. Orthologous to human ANXA7 (annexin A7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 48.4), bladder adult (RPKM 40.7) and 28 other tissues See more
Orthologs
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Genomic context

See Anxa7 in Genome Data Viewer
Location:
14 A3; 14 11.53 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20505344..20530009, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20455261..20480133, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3105 Neighboring gene RIKEN cDNA 7330404K18 gene Neighboring gene mitochondrial ribosomal protein S16 Neighboring gene cilia and flagella associated protein 70 Neighboring gene STARR-seq mESC enhancer starr_36110 Neighboring gene MSS51 mitochondrial translational activator Neighboring gene STARR-seq mESC enhancer starr_36112 Neighboring gene protein phosphatase 3, catalytic subunit, beta isoform Neighboring gene RIKEN cDNA 1810062O18 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase-dependent fusogenic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTPase-dependent fusogenic activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of establishment of localization in cell IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of insulin secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular water homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_positive_effect ion channel modulating, G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_positive_effect ligand-gated ion channel signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within_positive_effect phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_positive_effect positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to salt stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with chromaffin granule membrane ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
annexin A7
Names
annexin VII
annexin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110794.2NP_001104264.1  annexin A7 isoform 1

    See identical proteins and their annotated locations for NP_001104264.1

    Status: VALIDATED

    Source sequence(s)
    AC121801
    Consensus CDS
    CCDS26845.1
    UniProtKB/Swiss-Prot
    Q07076, Q3TT33
    UniProtKB/TrEMBL
    Q922A2
    Related
    ENSMUSP00000066035.10, ENSMUST00000065504.17
    Conserved Domains (1) summary
    pfam00191
    Location:164229
    Annexin; Annexin
  2. NM_001374757.1NP_001361686.1  annexin A7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121801
    Consensus CDS
    CCDS88585.1
    UniProtKB/TrEMBL
    A0A2C9F2D2, Q3UYL7
    Conserved Domains (1) summary
    pfam00191
    Location:186251
    Annexin
  3. NM_001422107.1NP_001409036.1  annexin A7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121801
    UniProtKB/TrEMBL
    A0A2C9F2D2, Q3UYL7
  4. NM_001422108.1NP_001409037.1  annexin A7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121801
    UniProtKB/Swiss-Prot
    Q07076, Q3TT33
    UniProtKB/TrEMBL
    Q922A2
  5. NM_001422109.1NP_001409038.1  annexin A7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121801
    UniProtKB/TrEMBL
    Q922A2
  6. NM_001422110.1NP_001409039.1  annexin A7 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC121801
  7. NM_009674.4NP_033804.2  annexin A7 isoform 1

    See identical proteins and their annotated locations for NP_033804.2

    Status: VALIDATED

    Source sequence(s)
    AC121801
    Consensus CDS
    CCDS26845.1
    UniProtKB/Swiss-Prot
    Q07076, Q3TT33
    UniProtKB/TrEMBL
    Q922A2
    Related
    ENSMUSP00000153669.2, ENSMUST00000224975.2
    Conserved Domains (1) summary
    pfam00191
    Location:164229
    Annexin; Annexin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    20505344..20530009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)