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Slc25a5 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 [ Mus musculus (house mouse) ]

Gene ID: 11740, updated on 24-Jan-2023

Summary

Official Symbol
Slc25a5provided by MGI
Official Full Name
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5provided by MGI
Primary source
MGI:MGI:1353496
See related
Ensembl:ENSMUSG00000016319 AllianceGenome:MGI:1353496
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ant2
Summary
This gene encodes a transmembrane domain-containing protein that localizes to the mitochondrial inner membrane. The encoded protein facilitates the exchange of ADP from the cytoplasm with ATP from the mitochondria. Pseudogenes for this gene are found on multiple chromosomes. [provided by RefSeq, May 2015]
Expression
Ubiquitous expression in large intestine adult (RPKM 861.5), kidney adult (RPKM 667.1) and 27 other tissues See more
Orthologs
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Genomic context

See Slc25a5 in Genome Data Viewer
Location:
X A3.3; X 21.2 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (36059250..36062461)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (36795597..36798808)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene solute carrier family 25, member 43 Neighboring gene predicted gene, 23613 Neighboring gene mitochondrial dynamic related lncRNA Neighboring gene STING1 ER exit protein 1 Neighboring gene 60S ribosomal protein L39 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC101927

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP:ADP antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP:ADP antiporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables adenine nucleotide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidative phosphorylation uncoupler activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables proton transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adaptive thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenine nucleotide transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
involved_in erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial ADP transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial ADP transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial ATP transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial ATP transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mitochondrial membrane permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ADP/ATP translocase 2
Names
ADP, ATP carrier protein 2
adenine nucleotide translocase
adenine nucleotide translocator 2, fibroblast

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007451.4NP_031477.1  ADP/ATP translocase 2

    See identical proteins and their annotated locations for NP_031477.1

    Status: REVIEWED

    Source sequence(s)
    AK003467, BY280917, BY472909
    Consensus CDS
    CCDS30062.1
    UniProtKB/Swiss-Prot
    P51881, Q61311
    UniProtKB/TrEMBL
    A0A6P5P4Y5, Q545A2
    Related
    ENSMUSP00000016463.4, ENSMUST00000016463.4
    Conserved Domains (1) summary
    PTZ00169
    Location:7296
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    36059250..36062461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)