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Hex-t1 Hexokinase testis 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 117364, updated on 2-Nov-2024

Summary

Official Symbol
Hex-t1provided by FlyBase
Official Full Name
Hexokinase testis 1provided by FlyBase
Primary source
FLYBASE:FBgn0042711
Locus tag
Dmel_CG33102
See related
AllianceGenome:FB:FBgn0042711
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG33102; CG5443; CG54430; DHK-453; Dmel\CG33102; Hex; Hex-T1; HEX-t1; HK
Summary
Predicted to enable fructokinase activity and glucokinase activity. Predicted to be involved in canonical glycolysis; glucose 6-phosphate metabolic process; and intracellular glucose homeostasis. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in artery disease (multiple); glucose metabolism disease (multiple); obesity; and retinitis pigmentosa. Orthologous to several human genes including GCK (glucokinase); HK2 (hexokinase 2); and HK3 (hexokinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See Hex-t1 in Genome Data Viewer
Location:
97B2-97B3; 3-91 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26449079..26450585)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22274801..22276307)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43434 Neighboring gene taxi Neighboring gene Hexokinase testis 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables D-glucose binding IEA
Inferred from Electronic Annotation
more info
 
enables fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hexokinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in canonical glycolysis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glucose 6-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
hexokinase testis 1
Names
CG33102-PA
Hex-t1-PA
Hexokinase-t1
hexokinase
NP_788744.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26449079..26450585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176567.2NP_788744.1  hexokinase testis 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788744.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6AWE1, Q9NFT9, Q9VBF1
    Related
    FBpp0084382
    Conserved Domains (3) summary
    COG5026
    Location:13446
    COG5026; Hexokinase [Carbohydrate transport and metabolism]
    pfam00349
    Location:13209
    Hexokinase_1; Hexokinase
    pfam03727
    Location:215448
    Hexokinase_2; Hexokinase