Format

Send to:

Choose Destination

Ebp EBP, cholestenol delta-isomerase [ Rattus norvegicus (Norway rat) ]

Gene ID: 117278, updated on 12-Aug-2018

Summary

Official Symbol
Ebpprovided by RGD
Official Full Name
EBP, cholestenol delta-isomeraseprovided by RGD
Primary source
RGD:620957
See related
Ensembl:ENSRNOG00000004903
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
catalyses the conversion of 5-alpha-cholest-8-en-3-beta-ol to 5-alpha-cholest-7-en-3-beta-ol in cholesterol biosynthesis [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 233.6), Kidney (RPKM 57.0) and 7 other tissues See more
Orthologs

Genomic context

See Ebp in Genome Data Viewer
Location:
Xq12
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15049394..15055782)
104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (15832710..15839093)

Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene FtsJ RNA methyltransferase homolog 1 Neighboring gene similar to ribosomal protein L31 Neighboring gene porcupine O-acyltransferase Neighboring gene TBC1 domain family, member 25 Neighboring gene RNA binding motif protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
C-8 sterol isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-8 sterol isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
C-8 sterol isomerase activity ISO
Inferred from Sequence Orthology
more info
 
C-8 sterol isomerase activity TAS
Traceable Author Statement
more info
PubMed 
cholestenol delta-isomerase activity IEA
Inferred from Electronic Annotation
more info
 
steroid delta-isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid delta-isomerase activity ISO
Inferred from Sequence Orthology
more info
 
steroid delta-isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
cholesterol biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
sterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
sterol biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Names
D8-D7 sterol isomerase
cholestenol Delta-isomerase
delta(8)-Delta(7) sterol isomerase
emopamil binding protein (sterol isomerase)
emopamil-binding protein
phenylalkylamine Ca2+ antagonist (emopamil) binding protein
sterol 8-isomerase
NP_476478.1
XP_006256761.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_057137.1NP_476478.1  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

    See identical proteins and their annotated locations for NP_476478.1

    Status: PROVISIONAL

    Source sequence(s)
    AF071501
    UniProtKB/Swiss-Prot
    Q9JJ46
    Related
    ENSRNOP00000007015.4, ENSRNOT00000007015.6
    Conserved Domains (1) summary
    pfam05241
    Location:36216
    EBP; Emopamil binding protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

    Range
    15049394..15055782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256699.3XP_006256761.1  3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase isoform X1

    See identical proteins and their annotated locations for XP_006256761.1

    UniProtKB/Swiss-Prot
    Q9JJ46
    Conserved Domains (1) summary
    pfam05241
    Location:36216
    EBP; Emopamil binding protein

Alternate Rn_Celera

Genomic

  1. AC_000089.1 Alternate Rn_Celera

    Range
    14384941..14391269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center